Find P2RY1 Products Interaction Network for P2RY1 P2RY1 Details

Related Pathways G-Protein Coupled Receptor Signaling View All Pathways

Synonyms:P2RY1, P2y, P2Y1, P2y1 receptor

P2Y Receptor Signaling

Extracellular purine nucleotides are able to initiate cell signals through a superfamily of purinergic receptors. Purinergic P2 receptors respond differentially to ATP, ADP, UTP or UDP. There are two types of purinergic P2 receptors. Purinergic P2X receptors are ion channels, whereas P2Y receptors are G-protein coupled metabotrophic receptors. P2Y receptors are further divided on the basis of preferred agonists and their associated G-protein subunits. The eight known purinergic P2Y receptors subtypes include P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y subtypes 1, 2, 4, 6 and 11 are coupled to stimulation of phospholipase C through the G-protein alpha(q) (Gαq) subunits. P2Y11 is also associated with stimulation of adenylyl cyclase via a G-protein alpha(s) (Gαs) subunit. P2Y subtypes 12, 13 and 14 are linked to inhibition of adenylyl cyclase via G-protein alpha(i) (Gαi) subunits. Additional effects of agonist action on the P2Y receptor family are mediated by the G-protein betagamma dimer.

P2Y subtypes respond differentially to purine nucleotides. ATP is the preferred agonist of P2Y11 whereas; P2Y2 and P2Y4 are equally activated by ATP or UTP. ADP is the preferred agonist by P2Y1, P2Y6, P2Y12 and P2Y13. The agonist for P2Y14 is UDP-glucose. P2Y1 is widely expressed and it is involved in platelet aggregation, vasodilation and neuromodulation. The other factors are involved in a wide range of processes, such as ion flux, differentiation, and synaptic communication.

One area where P2Y receptor regulation has been studied involves the regulation of platelet aggregation. Platelet aggregation requires the costimulation of P2Y1 and P2Y12 by ADP. P2Y1 is linked to G-protein alpha(q) subunit activation which mediates activation of phospholipase C with subsequent elevation of intracellular calcium levels and activation of conventional and novel protein kinase Cs (PKC). These events allow platelet shape change and weak aggregation. P2Y12 is linked to G-protein alpha(i) subunit activation which inhibits adenylyl cyclase and lowers cAMP to basal levels. Together these actions facilitate platelet aggregation induced by ATP/ADP release during injury.