Find ARHGDIA Products Interaction Network for ARHGDIA ARHGDIA Details

Related Pathways Regulation of Actin-based Motility by Rho View All Pathways

Synonyms: 5330430M07Rik, ARHGDIA, Gdi-1, GDIA1, MGC101921, MGC117248, MGC7904, MGC94886, RHO GDI ALPHA, RhoDGI, RHOGDI, RHOGDI-1

RhoGDI Pathway

RhoGDI (Rho GDP-dissociation inhibitor) is a small family of proteins which includes the ubiquitous GDP dissociation inhibitor 1 (RhoGDIα) (RABGD1A) (Oligophrenin 2); RhoGDI-2 (RhoGDIβ) (D4), found primarily in haematopoietic cells, and RhoGDIgamma (RhoGDI-3), a membrane-anchored factor found in brain, pancreas, lung, kidney and testis. RhoGDIs regulate Rho subfamily GTPases including Rho, Rac and Cdc42. RhoGDIs have two major functions. They extract prenylated GDP:Rho-GTPases from membranes and sequester them as cytosolic complexes or transfer them to other membranes. They prevent the exchange of GTP for GDP on the Rho-GTPases by guanine nucleotide exchange factors, GEF. RhoGDIs control the action and status of the Rho-GTPases when they are not involved in the promotion of specific effector promoting activities.

Rho, Rac and Cdc42 are important molecular switches involved in the regulation of cytoskeletal structures that affect or enable the regulation of cell morphology, movement, attachment, phagocytosis and cytokinesis. Rho, Rac and Cdc42 are known to control these cell processes via the regulation of the formation of stress fibers; membrane ruffles/lamellipodia and filopodia, respectively. They are also involved in the regulation of gene transcription, cell cycle progression; vesicular trafficking and specialized functions such as activation of the NADPH oxidase complex in phagocytes (Rac1).