Find STAT3 Products Interaction Network for STAT3 STAT3 Details

Related Pathways JAK/Stat Signaling TREM1 Signaling IL-6 Signaling View All Pathways

Synonyms: 1110034C02Rik, acute-phase response factor, APRF, AW109958, FLJ20882, MGC128731, MGC16063, MGC93551, Stat1, STAT3, Stat3 alpha, Stat3 alpha isoform, Stat3 beta isoform, Stat3 delta

STAT3 Pathway

The four isoforms of STAT3 (Acute Phase Response Factor (APRF)): STAT3alpha (STAT3α); STAT3beta (STATβ); STAT3gamma (STAT3γ) and STAT3delta (STAT3δ) are members of the signal transducers and activators of transcription (STAT) protein family of transcription factors that bind as homo- and/or heterodimers to recognition sites such as the c-sis-inducible element (SIE) or gamma-activated site element (GAS) in gene promoters. STAT3α is expressed in most cells as a full-length isoform. STATβ is truncated alternatively spliced isoform. STAT3γ is produced by proteolysis of STAT3α.

STAT3 proteins are activated by a wide range of cytokines and growth factors. Cytokines typically activate STAT3 proteins through the JAK family of tyrosine kinases. STAT3 proteins are also activated via cytoplasmic kinases of the Src kinase family and by the tyrosine kinase activity of various (TKR) growth factor receptors. STAT3 proteins are differentially activated by cytokines that utilize the gp130 receptor component. Members of this family include: ciliary neurotrophic factor (CNTF), oncostatin M (OSM), leukemia-inhibitory factor (LIF) and interleukin-6 (IL-6). STAT3 proteins are also activated by growth hormone (GH); thrombopoietin (EPO), GCSF, GM-CSF, bFGF and many of the interleukins.

STAT3 is involved in embryonic stem (ES) cell self-renewal (stemness) of some mammalian cell types and species. In general, STAT3-mediated transcription directs cells into cell survival and cell-cycle progression. STAT3 participates in cellular transformation and tumorigenesis.