Zinc Finger Nuclease (ZFN)

CompoZr^® Zinc Finger Nuclease Technology

Zinc finger nucleases (ZFNs) are a class of engineered DNA-binding proteins that facilitate genome editing by creating a double-stranded break in DNA at a user-specified location.

A double-stranded break is important for site-specific mutagenesis in that it stimulates the cell’s natural DNA-repair processes, namely homologous recombination and Non-Homologous End Joining (NHEJ).

Using well-established and robust protocols, these cellular processes can be harnessed to generate precisely targeted in vitro or in vivo genomic edits with targeted gene deletions (Knockouts), integrations, or modifications.

CompoZr ZFNs – Now More Affordable

Improvements in CompoZr ZFN design and manufacturing have acted to significantly increase the affordability of genome editing with CompoZr ZFN technology for the research community.  All researchers now have access to this well characterized and highly published technology.

To learn more about the capability and availability of CompoZr ZFNs for genome editing click on the CompoZr Custom ZFN Service, Knockout ZFN or Targeted Integration Kit links below.

CompoZr ZFN Products

Learning Center: What is ZFN Technology? How do ZFNs Work? ZFNs in Animals ZFN expert, Dana Carroll talks about the technology Frank Sleutel’s lab from the Netherlands ZFN References FAQs Material Transfer Agreement (MTA) for ZFN-modified cell lines and non-animal derivatives

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