CompoZr Zinc Finger Nucleases (ZFNs) are a class of engineered DNA-binding proteins that facilitate highly specific targeted editing of any genome by creating double-stranded breaks in DNA at user specified locations. You can use ZFNs to create your choice of stable genetically engineered cell lines or organisms with gene deletions, gene integrations and gene modifications. The CompoZr Custom ZFN Service provides researchers with a functionally validated pair of ZFNs that have been custom designed and assembled to edit a target gene in a highly specific manner. Modify any gene in any biological system!
The following graphic highlights the abundance of genetic modifications that may be conducted using the Custom ZFN Service in any species or cell type.
|CSTZFND||CompoZr Custom Zinc Finger Nuclease - with ZFN Plasmid only||Check pricing|
||CompoZr Custom Zinc Finger Nuclease - with ZFN Plasmid and mRNA
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The Donor Design Service can be used in conjunction with functionally validated CompoZr ZFNs to perform precise genome modifications in a variety of organisms or cell lines. Researcher-defined specifications are used to design in-silico donor sequences in plasmid DNA or single-stranded DNA (oligo) format. Once the donor sequence is received researchers should have the donor synthesized in preparation for targeted integration with the appropriate CompoZr ZFNs.
For increased access to ZFN technology Sigma Life Science provides Custom ZFNs in two formats. The first format includes ZFNs as plasmids only, for an additional price ZFNs are provided as plasmids plus 10 aliquots of ready-to-use ZFN mRNA.
Researchers with human, mouse, rat and CHO ZFN projects receive the best performing pair of ZFNs after functional validation. Projects that are conducted in any other species are functionally validated in a yeast based assay and researchers will receive between 1-3 of the best performing ZFN pairs.
ZFN Custom Design Process
ZFN Candidate Design
ZFN Candidate Design Approval
ZFN Candidate Assembly
ZFN Candidate Validation
*Assumes successful validation of at least one pair of ZFNs from the initial design. Our on time delivery rate is > 80%.