Genome Editing

Zinc Finger Nuclease References

Publications

Human
Title Author / Journal
Systematic identification of functional residues in mammalian histone H2AX Chen, WT. et al. Mol Cell Biol, 2013; Jan, 33(1): 111-26
PARP1 is required for chromosomal translocations Wray, J. et al., Blood, 2013; May 23, 121(21): 4359-65
A novel therapeutic molecule against HTLV-1 infection targeting provirus Tanaka, A. et al., Leukemia, 2013; Feb 15, doi: 10.1038/leu.2013.46. Epub ahead of print
Zinc Finger Nuclease induced DNA double stranded breaks and rearrangements in MLL Do, T.U. et al., Mutat Res., 2012; Dec 7, 740(1-2): 34-42
A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation Bentley, C. et al. Biochem J., 2013; June 1, 452(2): 313-20.
The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells Gutschner, T. et al. Cancer Res., 2012 Dec. 14; Advance Online Publication
Obligate Ligation-Gated Recombination (ObLiGaRe): Custom designed nucleases mediated targeted integration through non-homologous end joining Maresca, M. et al. Genome Res., 2012 Nov. 14; Advance Online Publication
A Zinc Finger Nuclease Assay to Rapidly Quantitate Homologous Recombination Proficiency in Human Cell Lines Yuan, J. et al. Anal Biochem., 2012 Nov. 10; Advance Online Publication
Zinc-finger nuclease-mediated correction of a-thalassemia in iPS cells Chang, CJ. et al. Blood, 2012 Sep. 21; Advance Online Publication
Genome editing of human embryonic stem cells and induced pluripotent stem cells and zinc finger nuclease for cellular imaging Wang, Y. et al. Circ Res., 2012 Sep. 11; Advance Online Publication
Lysine methylation of VCP by a member of a novel human protein methyltransferase family Kernstock, S. et al. Nat Commun., 2012 Sept 4; 3:1038
Loss of abundant nuclear non-coding RNA MALAT1 is compatible with life and development Eibmann, M. et al. RNA Biol., 2012 Aug 1;9(8); Advance Online Publication
Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc-finger nuclease glycoengineered SimpleCells Schjoldager, KT. et al. Proc Natl Acad Sci U.S.A., 2012 May 7; Advance Online Publication
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer Ng, KP. et al. Nat Med., 2012 Mar 18; 18(4):521-8
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer Provasi, E. et al. Nat Med., 2012 Apr 1; Advance Online Publication
Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment Yuan, J. et al. Mol Ther., 2012 Apr;20 (4): 849-59
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses Hayakawa, S. et al. Nat Immunol., 2011 Jan; 12(1):37-44
Targeted gene correction of a(1)-antitrypsin deficiency in induced pluripotent stem cells Yusa, K. et al. Nature, 2011 Oct 12; 478(7369):391-4
Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease Zou, J. et al. Blood, 2011 Oct 27; 118(17):4599-608
Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines Steentoft, C. et al. Nat Methods, 2011 Oct 9; 8(11):977-82
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors Le Floch, R. et al. Proc Natl Acad Sci U.S.A., 2011 Oct 4; 108(40):16663-8
Non-coding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases Gutschner, T. et al. Genome Res., 2011 Nov; 21(11):1944-54
Site-specific integration and tailoring of cassette design for sustainable gene transfer Lombardo, A. et al. Nat Methods, 2011 Aug 21; 8(10):861-9
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations Soldner, F. et al. Cell, 2011 Jul 22; 146(2):318-31
Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells Doyon, JB. et al. Nat Cell Biol., 2011 Mar; 13(3):331-7
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells Inami, Y. et al. J Cell Bio., 2011 Apr 18; 193(2):275-84
BMI1 is recruited to DNA breaks and contributes to DNA damage induced H2A ubiquitation and repair Ginjala, V. et al. Mol Cell Biol., 2011 May; 31(10):1972-82
Oxidase deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease mediated safe harbor targeting Zou, J. et al. Blood, 2011 May 26; 117(21):5561-72
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome DeKelver, RC. et al. Genome Res., 2010 Aug; 20(8):1133-42
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo Holt, N. et al. Nat Biotechnol., 2010 Aug; 28(8):839-47
Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology Orlando, SJ. et al. Nucleic Acids Res., 2010 Aug; 38(15):e152
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases Hockemeyer, D. et al. Nat Biotechnol., 2009 Sep; 27(9):851-7
Chromosomal translocations induced at specified loci in human stem cells Brunet, E. et al. Proc Natl Acad Sci U.S.A., 2009 Jun 30; 106(26):10620-5
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases Perez, EE. et al. Nat Biotechnol., 2008 Jul; 26(7):808-16
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA Minczuk, M. et al. Nucleic Acids Res, 2008 Jul; 36(12):3926-38
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery Lombardo, A. et al. Nat Biotechnol., 2007 Nov; 25(11):1298-306
Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases Moehle, EA. et al. Proc Natl Acad Sci U.S.A., 2007 Feb 27; 104(9):3055-60
Highly efficient endogenous human gene correction using designed zinc-finger nucleases Urnov, FD. et al. Nature, 2005 Jun 2; 435(7042):646-51  
     
Rat
Title Author / Journal
Derivation and Genetic Modification of Embryonic Stem Cells from Disease-Model Inbred Rat Strains Yang, s. et al., Stem Cells Dev, 2013; May 1, Epub ahead of print
Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage Mattason. D.L. et al., Am J Physiol Regul Integr Comp Physiol., 2013; Mar 15, 304(6):R407-14
Heterozygous knockout of transforming growth factor-ß1 protects Dahl S rats against high salt-induced renal injury Chen, C.C. et al., Physiol Genomics, 2013; Feb 4, 45(3): 110-8
Two distinct knockout approaches highlight a critical role of p53 in rat development Kawamata, M. et al. Sci Rep., 2012 Dec 10; Advance Online Publication
Targeted disruption of Adamts16 gene in a rat genetic model of hypertension Gopalakrishnan, K. et al. Proc Natl Acad Sci USA., 2012 Nov 26; Advance Online Publication
Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat Zschemisch, NH. et al. BMC Immunology., 2012 Nov 8; Advance Online Publication
Generation and Characterization of Severe Combined Immunodeficiency Rats Mashimo, T. et al. Cell Rep., 2012 Sep 11; Advance Online Publication
Creation and Preliminary Characterization of a Leptin Knockout Rat Vaira, S. et al. Endocrinology., 2012 Sep 4; Advance Online Publication
Creation and preliminary characterization of a Tp53 knockout rat McCoy, A. et al. Dis Model Mech., 2012 Aug 23; Advance Online Publication
Deletion of Abcg2 has Differential Effects on Excretion and Pharmacokinetics of Probe Substrates in Rats Huang, L. et al. J Pharmacol Exp Ther., 2012 August 6; Advance Online Publication
Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension Feng, D. et al. Cell Metab., 2012 Feb 8; 15(2):201-8
Characterization of Mdr1a/P-glycoprotein Knockout Rats Generated by Zinc Finger Nucleases Chu, X. et al. Mol Pharmacol., 2011 Nov 2; Advance Online Publication
Creation and characterization of a renin knockout rat Moreno, C. et al. Hypertension, 2011 Mar; 57(3):614-9
Targeted integration in rat and mouse embryos with zinc-finger nucleases Cui, X. et al. Nat Biotechnol., 2011 Jan; 29(1):64-7
Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases Mashimo, T. et al. PLoS One, 2010 Jan 25; 5(1):e8870
Generation of gene-specific mutated rats using zinc-finger nucleases Geurts, AM. et al. Methods Mol Biol., 2010; 597:211-25
Knockout rats via microinjection of zinc-finger nucleases Geurts, AM. et al. Science, 2009 Jul 24; 325(5939):433
   
Mouse
Title Author / Journal
Self-formation of functional adenohypophysis in three-dimensional culture Suga, H. et al. Nature, 2011 Nov 9; 480(7375):57-62
In vivo genome editing restores haemostasis in a mouse model of haemophilia Li, H. et al. Nature, 2011 Jun 26; 475(7355):217-21
Targeted integration in rat and mouse embryos with zinc-finger nucleases Cui, X. et al. Nat Biotechnol., 2011 Jan; 29(1):64-7
Targeted genome modification in mice using zinc-finger nucleases Carbery, ID. et al. Genetics, 2010 Oct; 186(2):451-9
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases Meyer, M. et al. Proc Natl Acad Sci U.S.A., 2010 Aug 24; 107(34):15022-6
Distinct factors control histone variant H3.3 localization at specific genomic regions Goldberg, AD, et al. Cell, 2010 Mar 5; 140(5):678-91
   
Zebrafish
Title Author / Journal
Efficient Methods for Targeted Mutagenesis in Zebrafish Using Zinc-Finger Nucleases: Data from Targeting of Nine Genes Using CompoZr or CoDA ZFNs Sood, R. et al. PLoS One, 2013; Feb 22, 8(2): e57239
Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes van Bebber, F. et al. J Neurochem, 2013;  Feb 14, doi: 10.1111/jnc.12198, Epub ahead of print
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth Schmid, B. et al. PNAS, 2013; Mar 26, 110 (13): 4986-4991. 
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases Meng, X. et al. Nat Biotechnol., 2008 Jun; 26(6):695-701
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases Doyon, Y. et al. Nat Biotechnol., 2008 Jun; 26(6):702-8
   
Plasmodium
Title Author / Journal
Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases Straimer, J. et al. Nat Methods., 2012 Aug 26; Advance Online Publication
   
Xenopus
Title Author / Journal
Generation of albino Xenopus tropicalis using zinc-finger nucleases Nakajima, K. et al. Dev Growth Differ., 2012 Oct 29; Advance Online Publication
Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases Young, JJ. et al. Proc Natl Acad Sci U.S.A., 2011 Apr 26; 108(17):7052-7
   
Rainbow Trout
Title Author / Journal
An Immune-Related Gene Evolved into the Master Sex-Determining Gene in Rainbow Trout, Oncorhynchus mykiss Yano, A. et al. Curr Biol., 2012 Jun 20. Advance Online Publication
   
Mosquito
Title Author / Journal
orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET DeGennaro, M. et al., Nature, 2013; May 29 doi: 10.1038/nature12206, Epub ahead of print.
   
Pig
Title Author / Journal
Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose a-1,3-Galactose reduce the humoral barrier to xenotransplantation Lutz, . Et al., Xenotransplantation, 2013; Jan-Feb, 20(1): 27-35.
Biallelic knockout of the a-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases Li, P. et al. J Surg Res., 2012 Jul 3. Advance Online Publication
Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases Hauschild, J. et al. Proc Natl Acad Sci U.S.A., 2011 Jul 19; 108(29):12013-7
Generation of PPAR? mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning Yang, D. et al. Cell Res., 2011 Jun; 21(6):979-82
Gene targeting with zinc finger nucleases to produce cloned eGFP knockout pigs Whytte, JJ. et al. Mol Reprod Dev., 2011 Jan; 78(1):2
Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases Watanabe, M. et al. Biochem Biophys Res Commun., 2010 Nov 5; 402(1):14-8
   
Rabbit
Title Author / Journal
Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases Flisikowska, T. et al. PLos One, 2011;6(6): e21045
   
Cattle
Title Author / Journal
Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle Yu, S. et al. Cell Res., 2011 Nov; 21(11):1638-40
   
CHO
Title Author / Journal
Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production Misaghi, S. et al., Biotechnol Prog., 2013; Apr 18, Epub ahead of print.
In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration Cristea, S. et al. Biotechnol Bioeng., 2012 Oct 5, Advance Online Publication
Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells Fan, L., et al. Biotechnol Bioeng., 2012 Apr;109 (4):1007-15
Dissection of splicing regulation at an endogenous locus by zinc-finger nuclease-mediated gene editing Cristea, S. et al. Plos One, 2011 Feb 8; 6(2): e16961
Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies Malphettes, L. et al. Biotechnol Bioeng., 2010 Aug 1; 106(5):774-83
Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology Orlando, SJ. et al. Nucleic Acids Res., 2010 Aug; 38(15): e152
BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells Cost, GJ. et al. Biotechnol Bioeng., 2010 Feb 1; 105(2):330-40
Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases Liu, PQ. et al. Biotechnol Bioeng., 2010 May 1; 106(1):97-105
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases Santiago, Y. et al. Proc Natl Acad Sci U.S.A., 2008 Apr 15; 105(15):5809-14
   
ZFN Technology
Title Author / Journal
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins Gaj, T., et al. Nat Methods, 2012 Jul 1; 9(8):805-7
High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases Chen, F. et al. Nat Methods, 2011 Jul 17; 8(9):753-5
Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures Doyon, Y. et al. Nat Methods, 2011 Jan; 8(1):74-9
Transient cold shock enhances zinc-finger nuclease-mediated gene disruption Doyon, Y. et al. Nat Methods, 2010 Jun; 7(6):459-60
An improved zinc-finger nuclease architecture for highly specific genome editing Miller, JC. et al. Nat Biotechnol., 2007 Jul; 25(7):778-85
   
Reviews
Title Author / Journal
Cell Biology Symposium: Zinc finger nucleases to create custom-designed modifications in the swine (Sus scrofa) genome Whyte, JJ. et al. J Anim Sci., 2012 Apr;90 (4):1111-17
On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools Duranthon, V. et al. Transgenic Res., 2012 Mar 2. Advance Online Publication
Genome editing with engineered zinc finger nucleases Urnov, FD. et al. Nat Rev Genet., 2010 Sep; 11(9):636-46
Gene targeting in the rat: advances and opportunities Jacob, HJ. et al. Trends Genet., 2010 Dec; 26(12):510-8
Zinc-finger nucleases: new strategies to target the rat genome Geurts, AM. et al. Clin Sci (Lond), 2010 Jul 6; 119(8):303-11
   
Posters
Title  
Applications of Zinc Finger Nucleases
Expression of miRNA Genes Using Targeted Genomic Integration (185 Kb PDF)
Precision Genome Editing in Mammalian Cells Using Engineered Zinc Finger Proteins (834 Kb PDF)
An Application of Zinc Finger Nuclease Technology to Create Knockout Cancer Lines (982 Kb PDF)
Breast Cancer Pathway Investigation Facilitated Using ZFN Technology (1.29 Mb PDF)
An Application of Zinc Finger Nuclease Technology to Create Multiple Complete Gene Knockouts in Polyploid Cancer Lines (1.08 Mb PDF)
Development of Gene-Specific Knock-in Reporter Cell Lines via ZFN-Mediated Homologous Recombination (2.00 Mb PDF)
Tagging Endogenous Genes with Fluorescent Reporters using CompoZr Zinc Finger Nuclease Technology (1.7 Mb PDF)
An Application of Zinc Finger Nuclease Technology to Create Knock-in and Knock-out Cell Lines (1.23 Mb PDF)
Development of Novel Knock-in Cell Lines with Target Genes Endogenously Tagged by Fluorescent Reporters Utilizing Zinc Finger Nuclease Technology (1.88 Mb PDF)
Targeted Integration of Fluorescent Reporter Genes Utilizing Zinc Finger Nucleases (1.44 Mb PDF)
ZFN Assisted Targeted Integration to Develop Knock-in Reporter Cell Lines (961 Kb PDF)
   
Label License
Title  
ZFN License Agreement
   

back to CompoZr ZFN Technology homepage
back to top