|
Functional Genomics & RNAi
CompoZr® Zinc Finger Nuclease References
|
|
|
Publications
Posters
Label License
Publications
Gene Knockout:
Liu, P. et al. 2010. Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases. Biotechnol Bioeng. Advance Online Publication.
Cost, G.J. et al. 2010. BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells. Biotechnol Bioeng. 105(2): 330-40.
Santiago, Y. et al. 2008. Targeted gene knockout in mammalian cells using engineered zinc finger nucleases. Proc Natl Acad Sci USA. 105(15): 5809-14.
Perez, E.E. et al. 2008. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol. 26: 808–816.
Endogenous Gene Correction:
Urnov, F. D. et al. 2005. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature. 435(7042): 646-51.
Endogenous Gene Tagging:
Goldberg, A.D., et al. 2010. Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions. Cell. 140(5): 678-691.
Targeted Gene Integration:
Moehle, E.A. et al. 2007. Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proc Natl Acad Sci USA. 104(9): 3055-60.
Stem Cell Gene Manipulation:
Hockemeyer, D. et al. 2009. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol. 27(4): 851-7.
Brunet, E. et al. 2009. Chromosomal translocations induced at specified loci in human stem cells. Proc Natl Acad Sci USA. 105(26):10620–5.
Lombardo, A. et al. 2007. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol. 25(11): 1298-306.
Animal Gene Manipulation:
Mashimo, T. et al., 2010. Generation of Knockout Rats with X-linked Severe Combined Immunodeficiency (X-SCID) using Zinc Finger Nucleases. PLoS ONE 5(1): e8870.
Geurts, A.M. et al., 2009. Knockout rats via embryo microinjection of zinc-finger nucleases. Science. 325(5939): 433.
Doyon, Y. et al. 2008. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat Biotechnol. 26(6): 702.
Zinc Finger Protein Specificity:
Miller, J.C. et al. 2007. An improved zinc-finger nuclease architecture for highly specific genome editing. Nat Biotechnol. 25(7): 778-85.
Targeting of Mitochondrial DNA:
Minczuk, M. et al. 2008. Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA. Nucleic Acids Research. 36(12): 3926-38.
Posters
Expression of miRNA Genes Using Targeted Genomic Integration (185 Kb PDF)
Precision Genome Editing in Mammalian Cells Using Engineered Zinc Finger Proteins (834 Kb PDF)
An Application of Zinc Finger Nuclease Technology to Create Knockout Cancer Lines (982 Kb PDF)
Label License
ZFN License Agreement
back to CompoZr ZFN Technology homepage
