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Life Science > Zinc Finger Nuclease (ZFN) > Zinc Finger Nuclease References
Functional Genomics & RNAi

Zinc Finger Nuclease References

Publications



Human
Title Author / Journal
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses Hayakawa, S. et al. Nat Immunol., 2011 Jan; 12(1):37-44
Targeted gene correction of α(1)-antitrypsin deficiency in induced pluripotent stem cells Yusa, K. et al. Nature, 2011 Oct 12; 478(7369):391-4
Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease Zou, J. et al. Blood, 2011 Oct 27; 118(17):4599-608
Mining the O-glycoproteome using zinc-finger nuclease-glycoengineered SimpleCell lines Steentoft, C. et al. Nat Methods, 2011 Oct 9; 8(11):977-82
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors Le Floch, R. et al. Proc Natl Acad Sci U.S.A., 2011 Oct 4; 108(40):16663-8
Non-coding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases Gutschner, T. et al. Genome Res., 2011 Nov; 21(11):1944-54
Site-specific integration and tailoring of cassette design for sustainable gene transfer Lombardo, A. et al. Nat Methods, 2011 Aug 21; 8(10):861-9
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations Soldner, F. et al. Cell, 2011 Jul 22; 146(2):318-31
Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells Doyon, JB. et al. Nat Cell Biol., 2011 Mar; 13(3):331-7
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells Inami, Y. et al. J Cell Bio., 2011 Apr 18; 193(2):275-84
BMI1 is recruited to DNA breaks and contributes to DNA damage induced H2A ubiquitation and repair Ginjala, V. et al. Mol Cell Biol., 2011 May; 31(10):1972-82
Oxidase deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease mediated safe harbor targeting Zou, J. et al. Blood, 2011 May 26; 117(21):5561-72
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome DeKelver, RC. et al. Genome Res., 2010 Aug; 20(8):1133-42
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo Holt, N. et al. Nat Biotechnol., 2010 Aug; 28(8):839-47
Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology Orlando, SJ. et al. Nucleic Acids Res., 2010 Aug; 38(15):e152
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases Hockemeyer, D. et al. Nat Biotechnol., 2009 Sep; 27(9):851-7
Chromosomal translocations induced at specified loci in human stem cells Brunet, E. et al. Proc Natl Acad Sci U.S.A., 2009 Jun 30; 106(26):10620-5
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases Perez, EE. et al. Nat Biotechnol., 2008 Jul; 26(7):808-16
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA Minczuk, M. et al. Nucleic Acids Res, 2008 Jul; 36(12):3926-38
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery Lombardo, A. et al. Nat Biotechnol., 2007 Nov; 25(11):1298-306
Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases Moehle, EA. et al. Proc Natl Acad Sci U.S.A., 2007 Feb 27; 104(9):3055-60
Highly efficient endogenous human gene correction using designed zinc-finger nucleases Urnov, FD. et al. Nature, 2005 Jun 2; 435(7042):646-51
   
Mouse
Title Author / Journal
Self-formation of functional adenohypophysis in three-dimensional culture Suga, H. et al. Nature, 2011 Nov 9; 480(7375):57-62
In vivo genome editing restores haemostasis in a mouse model of haemophilia Li, H. et al. Nature, 2011 Jun 26; 475(7355):217-21
Targeted integration in rat and mouse embryos with zinc-finger nucleases Cui, X. et al. Nat Biotechnol., 2011 Jan; 29(1):64-7
Targeted genome modification in mice using zinc-finger nucleases Carbery, ID. et al. Genetics, 2010 Oct; 186(2):451-9
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases Meyer, M. et al. Proc Natl Acad Sci U.S.A., 2010 Aug 24; 107(34):15022-6
Distinct factors control histone variant H3.3 localization at specific genomic regions Goldberg, AD, et al. Cell, 2010 Mar 5; 140(5):678-91
   
Rat
Title Author / Journal
Characterization of Mdr1a/P-glycoprotein Knockout Rats Generated by Zinc Finger Nucleases Chu, X. et al. Mol Pharmacol., 2011 Nov 2; Advance Online Publication
Creation and characterization of a renin knockout rat Moreno, C. et al. Hypertension, 2011 Mar; 57(3):614-9
Targeted integration in rat and mouse embryos with zinc-finger nucleases Cui, X. et al. Nat Biotechnol., 2011 Jan; 29(1):64-7
Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases Mashimo, T. et al. PLoS One, 2010 Jan 25; 5(1):e8870
Generation of gene-specific mutated rats using zinc-finger nucleases Geurts, AM. et al. Methods Mol Biol., 2010; 597:211-25
Knockout rats via microinjection of zinc-finger nucleases Geurts, AM. et al. Science, 2009 Jul 24; 325(5939):433
   
Zebrafish
Title Author / Journal
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases Meng, X. et al. Nat Biotechnol., 2008 Jun; 26(6):695-701
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases Doyon, Y. et al. Nat Biotechnol., 2008 Jun; 26(6):702-8
   
Frog
Title Author / Journal
Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases Young, JJ. et al. Proc Natl Acad Sci U.S.A., 2011 Apr 26; 108(17):7052-7
   
Pig
Title Author / Journal
Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases Hauschild, J. et al. Proc Natl Acad Sci U.S.A., 2011 Jul 19; 108(29):12013-7
Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning Yang, D. et al. Cell Res., 2011 Jun; 21(6):979-82
Gene targeting with zinc finger nucleases to produce cloned eGFP knockout pigs Whytte, JJ. et al. Mol Reprod Dev., 2011 Jan; 78(1):2
Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases Watanabe, M. et al. Biochem Biophys Res Commun., 2010 Nov 5; 402(1):14-8
   
Rabbit
Title Author / Journal
Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases Flisikowska, T. et al. Plos One, 2011;6(6): e21045
   
Cattle
Title Author / Journal
Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle Yu, S. et al. Cell Res., 2011 Nov; 21(11):1638-40
   
CHO
Title Author / Journal
Dissection of splicing regulation at an endogenous locus by zinc-finger nuclease-mediated gene editing Cristea, S. et al. Plos One, 2011 Feb 8; 6(2): e16961
Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies Malphettes, L. et al. Biotechnol Bioeng., 2010 Aug 1; 106(5):774-83
Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology Orlando, SJ. et al. Nucleic Acids Res., 2010 Aug; 38(15): e152
BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells Cost, GJ. et al. Biotechnol Bioeng., 2010 Feb 1; 105(2):330-40
Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases Liu, PQ. et al. Biotechnol Bioeng., 2010 May 1; 106(1):97-105
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases Santiago, Y. et al. Proc Natl Acad Sci U.S.A., 2008 Apr 15; 105(15):5809-14
   
ZFN Technology
Title Author / Journal
High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases Chen, F. et al. Nat Methods, 2011 Jul 17; 8(9):753-5
Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures Doyon, Y. et al. Nat Methods, 2011 Jan; 8(1):74-9
Transient cold shock enhances zinc-finger nuclease-mediated gene disruption Doyon, Y. et al. Nat Methods, 2010 Jun; 7(6):459-60
An improved zinc-finger nuclease architecture for highly specific genome editing Miller, JC. et al. Nat Biotechnol., 2007 Jul; 25(7):778-85
   
Reviews
Title Author / Journal
Genome editing with engineered zinc finger nucleases Urnov, FD. et al. Nat Rev Genet., 2010 Sep; 11(9):636-46
Gene targeting in the rat: advances and opportunities Jacob, HJ. et al. Trends Genet., 2010 Dec; 26(12):510-8
Zinc-finger nucleases: new strategies to target the rat genome Geurts, AM. et al. Clin Sci (Lond), 2010 Jul 6; 119(8):303-11
   
Posters
Title  
Applications of Zinc Finger Nucleases
Expression of miRNA Genes Using Targeted Genomic Integration (185 Kb PDF)
Precision Genome Editing in Mammalian Cells Using Engineered Zinc Finger Proteins (834 Kb PDF)
An Application of Zinc Finger Nuclease Technology to Create Knockout Cancer Lines (982 Kb PDF)
Breast Cancer Pathway Investigation Facilitated Using ZFN Technology (1.29 Mb PDF)
An Application of Zinc Finger Nuclease Technology to Create Multiple Complete Gene Knockouts in Polyploid Cancer Lines (1.08 Mb PDF)
Development of Gene-Specific Knock-in Reporter Cell Lines via ZFN-Mediated Homologous Recombination (2.00 Mb PDF)
Tagging Endogenous Genes with Fluorescent Reporters using CompoZr Zinc Finger Nuclease Technology (1.7 Mb PDF)
An Application of Zinc Finger Nuclease Technology to Create Knock-in and Knock-out Cell Lines (1.23 Mb PDF)
Development of Novel Knock-in Cell Lines with Target Genes Endogenously Tagged by Fluorescent Reporters Utilizing Zinc Finger Nuclease Technology (1.88 Mb PDF)
Targeted Integration of Fluorescent Reporter Genes Utilizing Zinc Finger Nucleases (1.44 Mb PDF)
ZFN Assisted Targeted Integration to Develop Knock-in Reporter Cell Lines (961 Kb PDF)
   
Label License
Title  
ZFN License Agreement
   

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