Poly(2-oxazoline)

Poly(2-oxazolines) are hydrophilic, biocompatible polymers typically used in drug, protein, and gene delivery. Poly(2-oxazolines) are a low viscosity alternative to PEGs with similar “stealth” properties, but without adverse effects or accumulation.1,2 Poly(2-oxazolines) are synthesized using living cationic ring-opening polymerization techniques in order to produce polymers with highly controlled polymer composition, chain length, architecture and functionality. In drug delivery, poly(2-oxazolines) have been used in drug or protein conjugates3,4 and as polymeric micelles5 to overcome the low water solubility and poor bioavailability of drugs.6

1) Gaertner, F. C., Luxenhofer, R., Blechert, B., Jordan, R., and Essler, M., J. Controlled Release 2007, 119, 291.

2) B. Pidhatika , M., Rodenstein , Y., Chen , E., Rakhmatullina , A. Muhlebach , C. Acikgoz , M. Textor , R. Konradi , Biointerphases 2012 , 7 , 1 .

3) Viegas, T. X., Bentley, M. D., Harris, J. M., Fang, Z., Yoon, K., Dizman, B., Weimer, R., Mero, A., Pasut, G., Veronese, F. Bioconjugate Chem. 2011, 22 (5), 976.

4) Mero, A., Pasut, G., Dalla, Via L., Fijten, M. W., Schubert, U. S., Hoogenboom, R., Veronese, F. M. J. Controlled Release 2008 2, 87.

5) Wang, C. H., Hsiue, G. H., J. Controlled Release 2005, 108, 140.

6) C. Weber , R. Hoogenboom , U. S. Schubert , Prog. Polym. Sci. 2012 , 37 , 686

Well-defined Poly(2-ethyl-2-oxazoline)

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740713 Poly(2-ethyl-2-oxazoline) average Mn 5,000, PDI ≤1.2
741906 Poly(2-ethyl-2-oxazoline) average Mn 10,000, PDI ≤1.3
741884 Poly(2-ethyl-2-oxazoline) average Mn 25,000, PDI ≤1.4
778338 Poly(2-ethyl-2-oxazoline), alkyne terminated average Mn 5,000, PDI ≤1.2
747262 Poly(2-ethyl-2-oxazoline), alkyne terminated average Mn 2,000, PDI ≤1.3
809438 Poly(2-ethyl-2-oxazoline), α-benzyl, ω-thiol terminated average Mn 2,000, PDI <1.3
809446 Poly(2-ethyl-2-oxazoline), α-benzyl, ω-thiol terminated average Mn 10,000, PDI <1.3
773360 Poly(2-ethyl-2-oxazoline) α-methyl, ω-2-hydroxyethylamine terminated average Mn 2,000, PDI ≤1.2
773379 Poly(2-ethyl-2-oxazoline) α-methyl, ω-2-hydroxyethylamine terminated average Mn 5,000, PDI <1.3
773387 Poly(2-ethyl-2-oxazoline) α-methyl, ω-2-hydroxyethylamine terminated average Mn 10,000, PDI <1.3
900353 Ultroxa®: Poly(2-ethyl-2-oxazoline) average Mn 50,000, PDI ≤1.25
900359 Ultroxa®: Poly(2-ethyl-2-oxazoline) alkyne terminated average Mn 10,000, PDI ≤1.2
900360 Ultroxa®: Poly(2-ethyl-2-oxazoline) amine terminated average Mn 5,000, PDI ≤1.15
900355 Ultroxa®: Poly(2-ethyl-2-oxazoline) azide terminated average Mn 10,000, PDI ≤1.2
900357 Ultroxa®: Poly(2-ethyl-2-oxazoline) piperazine terminated average Mn 10,000, PDI ≤1.2

Well-defined Poly(2-methyl-2-oxazoline)

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778303 Poly(2-methyl-2-oxazoline), α-benzyl, ω-azide terminated average Mn 2,000, PDI <1.3
778311 Poly(2-methyl-2-oxazoline), α-benzyl, ω-azide terminated average Mn 5,000, PDI <1.3
795275 Poly(2-methyl-2-oxazoline), hydroxy terminated average Mn 2,000, PDI <1.2
795283 Poly(2-methyl-2-oxazoline), hydroxy terminated average Mn 5,000, PDI <1.3
900350 Ultroxa®: Poly(2-methyl-2-oxazoline) average Mn 10,000, PDI ≤1.2
900354 Ultroxa®: Poly(2-methyl-2-oxazoline) azide terminated average Mn 10,000, PDI ≤1.2
900358 Ultroxa®: Poly(2-methyl-2-oxazoline) piperazine terminated average Mn 10,000, PDI ≤1.2

Poly(2-ethyl-2-oxazoline)

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372846 Poly(2-ethyl-2-oxazoline) average Mw ~50,000, PDI 3-4
372854 Poly(2-ethyl-2-oxazoline) average Mw ~200,000, PDI 3-4
373974 Poly(2-ethyl-2-oxazoline) average Mw ~500,000, PDI 3-4

Well-defined Poly(2-propyl-2-oxazoline)

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900352 Ultroxa®: Poly(2-propyl-2-oxazoline) average Mn 10,000, PDI ≤1.2
900356 Ultroxa®: Poly(2-propyl-2-oxazoline) azide terminated average Mn 10,000, PDI ≤1.2