Polyphosphoesters

Polyphosphoesters exhibit many properties necessary for drug delivery and gene delivery.
  • Structurally similar to nucleic and teichoic acids.
  • Biodegrade through hydrolysis and possibly enzymatic digestion.
  • One of the few classes of polymers for non-viral gene delivery by conjugation of charged groups to the side chain of the phosphate.

References:
1. Zhan, Z. et. al. Adv. Drug Delv. Rev. 55, 483 (2003).
2. Penczek, S. et al. Polish J. Chem., 75, 1171 (2001).
3. Penczek, S. et al. Polish J. Chem., 68, 2129 (1994).

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659614 Poly[1,4-bis(hydroxyethyl)terephthalate-alt-ethyloxyphosphate] H2O: insoluble, but swells (opaque solution)
THF: insoluble
chloroform: soluble (readily)
hexane: insoluble
methylene chloride: soluble (readily)
659738 Poly[1,4-bis(hydroxyethyl)terephthalate-alt-ethyloxyphosphate]-co-1,4-bis(hydroxyethyl)terephthalate-co-terephthalate THF: insoluble, but swells
chloroform: soluble
hexane: insoluble, but swells
659606 Poly[(lactide-co-ethylene glycol)-co-ethyloxyphosphate] THF: soluble (readily)
acetonitrile: soluble (readily)
chloroform: soluble (readily)
ethyl acetate: soluble (readily)
hexane: insoluble