New EX-CELL® ANTIFOAM from SAFC Biosciences® Increases Consistency in Cell Culture Manufacturing

St. Louis, MO – November 19, 2009 – SAFC Biosciences®, a business segment of SAFC®, a member of the Sigma-Aldrich® Group (NASDAQ: SIAL), today announced the introduction of EX-CELL ANTIFOAM, a non-animal origin solution that enhances foam control in cell culture bioreactors to increase the consistency, efficiency and stability in cell culture manufacturing.

The EX-CELL ANTIFOAM solution is formulated from a 30% simethicone emulsion and validated by a simethicone quantification assay that confirms lot-specific concentration. This USP Grade non-ionic emulsion (simethicone) is designed for use in the pharmaceutical and veterinary biological industries to aid in the control of cell culture foaming in bioreactors. Through formulation optimization, utilization of a quantitative assay and understanding the non-specific binding of simethicone, SAFC Biosciences is able to report the actual simethicone concentration of the gamma irradiated finished material, producing a stable end product, thus ensuring product consistency, predictability and desired performance with at least a 13 month shelf life. EX-CELL ANTIFOAM is ready to use and should be directly supplemented into culture systems to prevent or eliminate foaming that occurs due to mixing and shear forces.

Bruce Lehr, SAFC Biosciences Director of Marketing, comments: "We anticipate strong market response to EX-CELL ANTIFOAM's improved performance and consistency. Our product development objectives continue to be heavily influenced by the market's desire for tools that facilitate consistency and efficiency in cell culture. We believe EX-CELL ANTIFOAM is another way of supporting those needs."

EX-CELL ANTIFOAM (Product No. 59920C) is available in 1 and 5 liter bags. Additional information is available at www.safcbiosciences.com/antifoam.

About SAFC Biosciences: SAFC Biosciences is a leading provider of cell culture materials and development services for upstream and downstream processes in the biopharmaceutical industry. Providing an integrated services package in mammalian cell culture media development, along with analytical and regulatory support, SAFC Biosciences employs a wealth of industry experience and scientific know-how to deliver reliable, consistent solutions that accelerate customer success – from development through to commercialization. The unit has a 35-year history as a manufacturing partner providing leading biopharmaceutical companies with the broadest range of highly customized products and services possible.

About SAFC: SAFC is the custom manufacturing and services group within Sigma-Aldrich that focuses on high-purity inorganics for high technology applications, cell culture products and services for biopharmaceutical manufacturing, biochemical production and the manufacturing of complex, multi-step organic synthesis of APIs and key intermediates. SAFC has manufacturing facilities around the world dedicated to providing manufacturing services for companies requiring a reliable partner to produce their custom manufactured materials. SAFC has four focus areas – SAFC Pharma®, SAFC Supply Solutions®, SAFC Biosciences® and SAFC Hitech® – and had annual sales of $620 million in 2008. SAFC is a top 10 fine chemical company. For more information about SAFC, visit www.safcglobal.com.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its chemical and biochemical products and kits are used in scientific research, including genomic and proteomic research, biotechnology, pharmaceutical development and as key components in pharmaceutical, diagnostic and other high technology manufacturing. The Company has customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use its products. Sigma-Aldrich operates in 38 countries and has 7,800 employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating Customer Success through Innovation and Leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit its award-winning Web site at www.sigma-aldrich.com.

Cautionary Statement: This release contains forward-looking statements relating to future performance, goals, strategic actions and initiatives and similar intentions and beliefs and other statements regarding the Companies' expectations, goals, beliefs, intentions and the like, which involve assumptions regarding the Companies' operations and conditions in the markets the Companies serve. The Companies do not undertake any obligation to update these forward-looking statements.

SAFC, SAFC Biosciences, SAFC Supply Solutions, SAFC Hitech, SAFC Pharma, Sigma-Aldrich and EX-CELL are registered trademarks of Sigma-Aldrich Biotechnology L.P. and Sigma-Aldrich Co.