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Standard RNA Phosphoramidite Proligo® Reagents Product Breadth of Proligo Reagents  Phosphoramidites: Pharmadite® DNA Phosphoramidites RNA Phosphoramidites 2'O-Methyl RNA Phosphoramidites 2'Fluoro Phosphoramidites DMT-2'Fluoro Phosphoramidites 5'-NPPOC Phosphoramidites  Fast Deprotection Chemistries: DNA RNA  Supports: Controlled Pore Glass (CPG) Columns  Solvents: Liquid Reagents Activator 42™  Modifications: Fluorescein Phosphoramidite Biotin Phosphoramidite Phosphate-ON Phosphoramidite Non Standard Nucleosides 6-FAM  Linkers: Amino Linkers ssH Linker Product Breadth of Proligo Reagents RNA plays a pivotal role in biological systems due to its numerous function in the transfer and processing of genetic information. The unique properties of RNA have stimulated the development of a variety of applications in diagnostics and therapeutics, as well as in basic molecular biology research where RNA can be used as: Catalytic agents (ribozymes) Affinity ligands (aptamers) Agents to induce gene silencing (RNA interference) Today, RNA interference (RNAi) has become a popular tool for the sequence-specific inhibition of gene expression and can be used in target validation and other drug development techniques. The most convenient method to provide sequence specific RNA oligonucleotides is chemical synthesis on a solid support with RNA phosphoramidites and RNA CPG, analogous to DNA synthesis. Key features of Standard RNA Amidites Industry standard 2'-TBDMS protective group Lot-to-lot consistent purity and performance Compatible with deprotection methods based on methylamine or AMA Standard RNA Amidites provide excellent coupling results when used together with ETT or BTT as activator; best results are obtained with Activator 42™1 Capping with standard acetic anhydride capping reagent rather than with Fast Deprotection Cap A Manufactured under a certified ISO 9001 quality system             Download Literature:   •  User Instructions Standard RNA Phosphoramidites (67k pdf)   •  RNA Phosphoramidites   View Structure:   •  rA(bz) Amidite   •  rC(ac) Amidite   •  rG(ib) Amidite   •  rU Amidite   RNA Phosphoramidites Compatible with Expedite™ and Polygen® Instruments Product No. Description Unit A212081-01 DMT-2'O-TBDMS-rA(bz) Amidite 1 x 0.5g C212081-01 DMT-2'O-TBDMS-rC(ac) Amidite 1 x 0.5g G212081-01 DMT-2'O-TBDMS-rG(ib) Amidite 1 x 0.5g U211081-01 DMT-2'O-TBDMS-rU Amidite 1 x 0.5g Compatible with ABI™ Instruments Product No. Description Unit A212031-01 DMT-2'O-TBDMS-rA(bz) Amidite 1 x 0.5g A212061-01 DMT-2'O-TBDMS-rA(bz) Amidite 1 x 1 g C212031-01 DMT-2'O-TBDMS-rC(ac) Amidite 1 x 0.5g C212061-01 DMT-2'O-TBDMS-rC(ac) Amidite 1 x 1 g G212031-01 DMT-2'O-TBDMS-rG(ib) Amidite 1 x 0.5g G212061-01 DMT-2'O-TBDMS-rG(ib) Amidite 1 x 1 g U211031-01 DMT-2'O-TBDMS-rU Amidite 1 x 0.5g U211061-01 DMT-2'O-TBDMS-rU Amidite 1 x 1 g   Other quantities and packaging are available upon request. 1Activator 42 = 5-(3,5-Bis(trifluoromethyl)phenyl)-1H-tetrazole, a very powerful activator for RNA- and DNA phosphoramidites, commercially available through SAFC Proligo Reagents. To order or speak with a Customer Service Representative, contact your local SAFC office. SAFC and SAFC Proligo Reagents are registered trademarks of Sigma-Aldrich Biotechnology, LP. ©2009 Sigma-Aldrich Biotechnology LP. All rights reserved. Reproduction forbidden without permission. Other trademarks are the property of their respective owners.