Certain features of will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Continuous Flow Chemistry

Since 2004 SAFC has employed flow chemistry as enabling technology to complement conventional batch chemistry. This helps our customers to access a wider scope of products and improves efficiency of typical reactions. SAFC’s multidisciplinary team of scientists, engineers and plant experts are able to develop and transfer a Continuous Flow Manufacturing project at any stage of the clinical pipeline – from discovery to commercial.

Why Choose SAFC?

  • Flexible, modular reactor design, readily adapted to various reaction types
  • Easy customization with access to any research equipment      
  • Wide range of capabilities with
    • reactors tolerate solids
    • temperature ranges from -80 to +300°C
    • full plant vessel support for batch processing as needed
  • Experience with a broad range of chemistry applications

Lean Manufacturing through Flow Chemistry

Continuous flow manufacturing is a lean manufacturing platform that provides customers access to as little or as much of a product as needed.

  • Cleaner reactions, higher yield and less raw material use, thanks to short reaction time
  • The very small reactant volume virtually eliminates risk of batch failure
  • Reduced labor, materials and waste
  • Isolation can be optimized to deliver end product directly 
  • Safer scale-up of not readily scalable by batch enhance the breadth of product offering

Typical Reactions

  • High temp or cryo reactions that are limited by scale
  • High volume products that require multiple runs
  • Reactions involving sensitive/unstable species
  • Reactions with material or construction issues
  • Hazardous intermediates/products or hazardous reactions

Seamless Scale-Up Capabilities

Research and Pilot Scale:

  • Throughput from mg to multi-kg per day
  • Operating temperature from -80° to +300°C
  • Pressure range 0 to 7 bar (0 to 100 psi)
  • Typical residence time 10 seconds to 10 minutes (extendable if needed)
  • Up to three chemical steps, batch work-up most typical
  • Mass flow meters and programmable logic control for accurate process control
  • Capable of handling thin slurries

Commercial Scale:

  • Throughput up to 150 kg per day
  • Operating temperature from -80 to +175°C
  • Pressure range from 0 to 8 bar (0 to 125 psi)
  • Residence time from 6 to 720 sec.
  • Flow Rate from 3 to 60 L/h
  • Digitally Controlled System (DCS)
  • Hastelloy construction C-276
Contact SAFC

Contract Manufacturing Inquiries
For product/service inquiries, quotes or information requests

Manufacturing Facilities
Related Links