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SFC Analysis of Aminoglutethimide Enantiomers on Astec® Cellulose DMP

SFC Analysis of Aminoglutethimide Enantiomers on Astec® Cellulose DMP

Conditions

column Astec Cellulose DMP, 25 cm x 4.6 mm I.D., 5 µm particles (51099AST)
mobile phase [A] CO2; [B] methanol containing 0.1% DEA in CO2; (75:25, A:B)
flow rate 3 ml/min
pressure 1740 psi (120 bar)
sample 2 mg/mL in methanol
injection 5 µl
detector UV, 230 nm

Description

Analysis Note This application demonstrates the ability of the Astec® Cellulose DMP column to separate Aminoglutethimide enantiomers via Supercritical Fluid Chromatography. DMPC-derivatized cellulose is widely used for chiral separations by SFC, both analytical and prep. The Astec® Cellulose DMP works well in SFC mode, providing rapid separations with excellent selectivity.
Categories Analytical Chromatography, SFC Applications
Featured Industry Pharmaceutical (small molecule)
Legal Information Astec is a registered trademark of Sigma-Aldrich Co. LLC
suitability application for SFC

Materials

     
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