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LC/MS (TOF) Analysis of 2C Amine Drugs of Abuse on Ascentis® Express HILIC

LC/MS (TOF) Analysis of 2C Amine Drugs of Abuse on Ascentis® Express HILIC


column Ascentis Express HILIC, 5 cm x 2.1 mm I.D., 2.7 µm particles (53934-U)
column temp. 35 C
mobile phase 2 mM ammonium formate in 90:10 (v:v) acetonitrile:water
flow rate 0.4 ml/min
pressure 943 psi (65 bar)
sample 300 ng/mL in acetonitrile
injection 2 µl
detector TOF/MS


Analysis Note The 2C amines are a family of illicit, psychedelic phenethylamines. The term "2C" refers to the two carbon atoms between the benzene ring and the amino group in the parent molecular structure. A rapid separation of four 2C amine compounds is shown here on an Ascentis Express HILIC column with TOF-MS detection. Cerilliant CRMs were used to ensure reliable MS identification and quantification.
Categories Analytical Chromatography, Forensics and Toxicology, drugs of abuse, Drugs of Abuse
Featured Industry Forensics and Toxicology
Legal Information Ascentis is a registered trademark of Sigma-Aldrich Co. LLC
suitability application for HPLC


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