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SFC Analysis of Metalaxyl Enantiomers on Astec® Cellulose DMP

SFC Analysis of Metalaxyl Enantiomers on Astec® Cellulose DMP


column Astec Cellulose DMP, 15 cm x 4.6 mm I.D., 5 µm particles (51098AST)
column temp. 35 C
mobile phase 20% methanol in CO2
flow rate 3 ml/min
pressure 1450 psi (100 bar)
sample 1 mg/mL in methanol
injection 5 µl
detector UV, 220 nm


Analysis Note Metalaxyl is a 1:1 mixture of (R)- and (S)-2-[(2,6-dimethylphenyl)methoxyacetylamino]propionic acid methyl ester. Both enantiomers are fungicides used in agriculture, horticulture, and forestry. They act by inhibiting mycelial growth and spore formation. Metalaxyl-M is the biologically active (R)-enantiomer. Technical-grade metalaxyl-M consists of a miniµm of 97% of the (R)-enantiomer and 3% of the (S)-enantiomer. Chiral LC on Astec Cellulose DMP was used to separate the two enantiomers.
Categories Analytical Chromatography, SFC Applications
Featured Industry Agriculture
Legal Information Astec is a registered trademark of Sigma-Aldrich Co. LLC
suitability application for SFC, application for HPLC


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