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UHPLC/MS Analysis of Various Drug Substances on Titan™ C18

UHPLC/MS Analysis of Various Drug Substances on Titan™ C18


column Titan C18, 5 cm x 2.1 mm I.D., 1.9 µm particles (577122-U)
column temp. 35 C
mobile phase [A] 5 mM ammonium formate; [B] 5 mM ammonium formate in 90:10 (v:v) acetonitrile:water
gradient 30 to 70% B in 3.0 min
flow rate 0.3 ml/min
sample 50 ng/mL in methanol
injection 3 µl
detector MS/MS


Analysis Note A Titan C18 column provided rapid, baseline resolution of this set of drug substances. The highest quality LC-MS solvents were used to supply low background interference and low particulate contaminants for robust, trouble-free operation. Cerilliant CRMs provided reliable identification and quantification.
Categories Analytical Chromatography, Pharmaceutical Analysis, Anticonvulsant/antiepiletic/antiseizure, Beta-blockers
Featured Industry Forensics and Toxicology, Pharmaceutical (small molecule)
Legal Information Titan is a trademark of Sigma-Aldrich Co. LLC
suitability application for HPLC


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