Benzodiazepine Standards

Benzodiazepines are a broad class of psychoactive drugs prescribed worldwide for treating numerous conditions from anxiety, seizures, and insomnia to muscle spasms, epilepsy, and alcohol withdrawal.1 Benzodiazepines are often combined into potentially lethal drug mixes by individuals with addiction disorders. Consumption of these drug mixes is associated with higher risk of overdose and mortality.2 Within the past several years, novel “designer” benzodiazepines such as phenazepam, etizolam, and nimetazepam have emerged in illicit online drug stores. Designer benzodiazepines are purportedly more potent than pharmaceutical benzodiazepines and are currently uncontrolled in many countries.3

Sigma-Aldrich's Cerilliant brand offers the widest selection of Certified Spiking Solutions® for benzodiazepines and their stable-labeled internal standards including a comprehensive list of parent compounds from alprazolam to triazolam in addition to a full offering of amino, hydroxyl, and glucuronide metabolites, and their internal standards. These certified reference solutions are suitable for numerous applications such as forensic analysis, clinical toxicology, urine drug testing, pharmaceutical research, or isotope dilution methods. Since these chemicals are generally controlled, Cerilliant supplies its Certified Spiking Solutions® of benzodiazepines in a USDEA and Health Canada with Test Kit Numbers (TK#s)-exempt solution format.

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