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Catecholamines

Catecholamines function as neurotransmitters and hormones within the body where they regulate and influence the activity of many complex physiological processes.1 Excessive production of catecholamines and their metabolites is a diagnostic indicator of catecholamine-producing tumors including phaeochromocytomas, paragangliomas, and neuroblastomas. The early and reliable diagnosis of these tumors is critical, since the tumoral secretion of catecholamines can lead to potentially lethal cardiovascular complications.2

Mass spectrometry-based methods are used to measure levels of catecholamines and their metabolites in cancer diagnostic testing applications.3 In recent years, interest in measuring 3-methoxytyramine (3MT), the O-methylated metabolite of dopamine, has surged as a result of new research highlighting its potential use as a biomarker of tumors that predominately secrete dopamine.4

Cerilliant’s catecholamine Certified Spiking Solutions® include multi-component mixes and stable-labeled internal standards of the parent hormones and their major metabolites. These solution Certified Reference Materials (CRMs) provide significant benefits to the laboratory including convenience of use, increased laboratory efficiency, and retest/expiration dates supported by real time stability data. Cerilliant certified reference solutions are manufactured and certified to the highest industry standards including ISO Guide 34, ISO/IEC 17025, and ISO 13485 and are compliant with ISO 15194.

Materials

     
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