Modulators and Proteins for Methylation

By: Savita Bagga, PhD., BioFiles v7 n3, 2012, 7–9

BioFiles Volume 7, Number 3 — Epigenetics

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DNA methyltransferases are a family of enzymes that catalyze the transfer of a methyl group to DNA. There are five related DNA cytosine-5-methyltransferases (DNMTs) that transfer a methyl group from S-adenosylmethionine (AdoMet, SAM) to the C-5 position of cytosine. Inhibitors of DNMT activity have been shown to have anti-proliferative activity. These inhibitors can reactivate the expression of genes that have been repressed by DNA methylation.

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