Neurotrophic Factors

By: Jennifer Fries, BioFiles 2009, 4.5, 19.

Neurotrophic factors are agents that are important for survival, growth, or differentiation of discrete neuronal populations. Based on amino acid sequence homologies of cytokines and receptors and based on similarities in cytokine-receptor binding characteristics, neurotrophic factors can be divided into three general families.1,2 The “neurotrophin family’’ includes nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrohin-3 (NT-3) and neurotrohin-4 (NT-4).3 The “CNTF family’’ includes ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF) and interleukin-6 (IL-6).2 Due to their broad biological actions, LIF and IL-6 are listed in separate sections. The “GDNF family’’ includes glial cell line derived neurotrophic factor (GDNF), neurturin (NTN), artemin (ART) and persephin (PSP).4

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Brain-derived Neurotrophic Factor (BDNF)

Product Description Source Recombinant Host Physical Form Assay Cell Type Affected Cat. No.
Brain-derived neurotrophic factor human Escherichia coli lyophilized powder The bioactivity is determined by its ability to stimulate the proliferation of rat C6 cells. basal forebrain cholinergic neuron hippocampal neuron placode-derived sensory neuron neural crest neuron retinal ganglial cell dopaminergic neuron B3795-5UG

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Ciliary Neurotrophic Factor (CNTF)

Product Description Source Recombinant Host Physical Form Assay Cell Type Affected Cat. No.
Ciliary Neurotrophic Factor human Escherichia coli lyophilized powder The proliferative activity is tested in a cell proliferation assay using the cytokinedependent human erythroleukemic cell line, TF-1. embryonic motor neuron dorsal root ganglion sensory neuron ciliary neuron hippocampal neuron C3710-10UG

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Nerve Growth Factor (Beta) NGF-Beta

Product Description Source Recombinant Host Physical Form Assay Cell Type Affected Cat. No.
NGF-β human mouse NSO cells lyophilized powder The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1. pheochromocytoma dorsal root ganglia cell adrenergic neuron N1408-.1MG
NGF-β from rat Sf21 cells lyophilized powder The biological activity is measured in a cell proliferation assay using the factor-dependent human erythroleukemic cell line, TF-1. adrenergic neuron pheochromocytoma dorsal root ganglia cell N2513-.1MG
NGF-β human Human HEK 293 cells lyophilized powder The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1. pheochromocytoma dorsal root ganglia cell adrenergic neuron N5415

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Nerve Growth Factor (NGF)

Product Description Source Recombinant Host Physical Form Assay Cell Type Affected Cat. No.
Nerve Growth Factor-7S from murine submaxillary gland - lyophilized powder The biological activity is measured using a 3-day MTT assay. adrenergic neuron pheochromocytoma dorsal root ganglia cell N0513-.1MG
Nerve Growth Factor-2.5S from murine submaxillary gland - lyophilized powder The biological activity is measured using a 3-day MTT assay. pheochromocytoma dorsal root ganglia cell adrenergic neuron N6009-.10UG
Nerve Growth Factor from Vipera lebetina venom - lyophilized powder The biological activity of Nerve Growth Factor from Vipera lebetina venom is measured in a cell proliferation assay using PC-12 cells. pheochromocytoma dorsal root ganglia cell adrenergic neuron N8133-.1MG

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Materials

     

References

  1. Henderson, C.E., Role of neurotrophic factors in neuronal development. Curr. Opinion Neurobiol., 6, 64-70 (1996).
  2. Frostick, S.P., et al., Schwann cells, neurothrophic factors, and peripheral nerve regeneration. Microsurgery, 18, 397-405 (1998).
  3. Barde, Y.-A., The nerve growth factor family-neurotrophins, in Guidebook to Cytokines and Their Receptors, Nicola, N., ed., Oxford Press (New York, N.Y.: 1994), pp. 140-143.
  4. Airaksinen, M.S., et al., GDNF family neurotrophic factor signaling: four masters, one servant? Molec. Cell. Neurosci., 13, 313-325 (1999).
  5. Sieber-Blum, M., Growth factor synergism and antagonism in early neural crest development. Biochem. Cell Biol., 76, 1039-1050 (1998).

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