Plasma Derived Proteins and Enzymes
BioFiles 2006, 1.5, 2.
Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,000 different proteins from about 500 gene products. Sigma-Aldrich has been isolating and purifying plasma and blood derived proteins for more than 40 years. As an original manufacturer, we offer the world's largest portfolio of proteins for research applications. Many of these proteins are produced on a large-scale custom basis under GMP for our manufacturing customers. For more extensive information on individual products and additional technical resources on plasma and blood related proteins and enzymes visit the Enzyme Explorer at sigma-aldrich.com/enzymeexplorer.
Plasma Protein Composition
| Protein | Amount in Normal Plasma (mg/100 mL) |
| α1-Acid glycoprotein | 55–140 |
| Albumin | 3500–5000 |
| α1-Antichymotrypsin | 30–60 |
| Antihemophilic factor (Factor VIII) | (1–2) |
| Antithrombin III | (20–40) |
| α1-Antitrypsin | 200–400 |
| Basic protein B1 | – |
| Basic protein B2 | <1 |
| γ Bence Jones protein | Trace |
| κ Bence Jones protein | Trace |
| Ceruloplasmin | 15–60 |
| Cholinesterase | 0.5–1.5 |
| Complement C1 Esterase inhibitor | 15–35 |
| Complement C1r Component | – |
| Complement C4 Binding Protein | – |
| Complement C8 Component | 8 |
| Complement C9 Component | 23 |
| Complement Factor B | |
| Complement Factor D | |
| Complement Factor H | |
| Complement C1q Component | 10–25 |
| Complement C1s Component | 1–2 |
| Complement C3 Component | 55–120 |
| Complement C4 Component | 20–50 |
| Complement C6 Component | 7 |
| Complement C2 Component | 2–3 |
| Complement C5 Component | 4–15 |
| Complement C7 Component | 6 |
| C-Reactive Protein | <1 |
| α1-Fetoprotein | ~1μg |
| Fibrinogen | 200–450 |
| Fibrin-stabilizing factor (Factor XIII) | (1–4) |
| Fibronectin | 25–40 |
| Galactoglycoprotein | |
| GC Globulin | 20–55 |
| 0.6 S γ2-Globulin | <1 |
| 2 S γ2-Globulin | 0.1 |
| 3.1 S Leucine-rich α2-glycoprotein | 2–3 |
| 3.8 S Histidine-rich α2-glycoprotein | 5–15 |
| 4 S α2, β1-Glycoprotein | Trace |
| 8 S α3-Glycoprotein | 3–5 |
| Zn-α2-Glycoprotein | 2–15 |
| α1B-Glycoprotein | 15–30 |
| α1T-Glycoprotein | 5–12 |
| α2HS-Glycoprotein | 40–85 |
| 9.5 S α1-Glycoprotein (serum amyloid P protein) | 3–8 |
| β2-Glycoprotein I | 15–30 |
| β2-Glycoprotein II | 12–30 |
| β2-Glycoprotein III | 5–15 |
| Haptoglobin Type 2–1 | 160–300 |
| Haptoglobin Type 1–1 | 100–220 |
| Haptoglobin Type 2–2 | 120–260 |
| Hemopexin | 50–115 |
| Immunoglobulin A | 90–450 |
| Immunoglobulin D | <15 |
| Immunoglobulin E | <0.06 |
| Immunoglobulin G | 800–1800 |
| Immunoglobulin M | 60–250 |
| Inter-α-trypsin inhibitor | 20–70 |
| Lysozyme | 0.5–1.5 |
| α2-Macroglobulin | 150–420 |
| α1-Microglobulin | 4–9 |
| β2-Microglobulin | Trace |
| Plasminogen | (6–25) |
| Post γ-globulin | – |
| Prealbumin, thyroxine-binding | 10–40 |
| Pregnancy-associated 2-glycoprotein | Trace |
| Properdin | 2–3 |
| Prothrombin | (5–10) |
| Retinol-binding protein | 3–6 |
| Thyroxine-binding globulin | 1–2 |
| Transcortin | ~7 |
| Transferrin | 200–320 |
From “The Plasma Proteins”, Volume IV, 2nd Edition, 1984, Frank W. Putnam.
