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Antibodies to Fas (CD95/Apo-1) and Fas Ligand (CD95L)

Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. The most well studied receptors are CD95/Fas/Apo-1 (apoptosis inducing protein 1) and tumor necrosis factor receptor 1 (TNFR1). Apoptosis mediated by either of these results in activation of the caspases. However, Fas-mediated death occurs much more rapidly than that triggered by TNFR1.

Human Fas/CD95/Apo-1 is a single transmembrane glycoprotein receptor (325 amino acids, 45-48 kDa). The Fas ligand (Fas ligand, FasL, CD95L) is an integral membrane protein and is a type II transmembrane glycoprotein. FasL is a member of the TNF family, which includes TNFα, α- and β-chains of lymphotoxin (LT), CD40 ligand and CD30 ligand. The action of Fas is mediated via FADD (Fas-associated death domain)/MORT1, an adapter protein that has a death domain at its C-terminus and binds to the cytoplasmic death domain of Fas.

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