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Preface

Sigma-Aldrich is pleased to provide this on-line version of the 5th edition of The Handbook of Receptor Classification and Signal Transduction. This edition has been updated to keep pace with the advances related to key receptors and signaling enzymes that are the focus of cell signaling research. Updated references and the inclusion of new pharmacological tools make this resource even more valuable to your research.

The Handbook of Receptor Classification and Signal Transduction provides a central reference to a broad spectrum of life science researchers, presenting concise information on the characterization and classification of a wide range of receptors, ion channels, transporters, neurotransmitter synthesis/metabolism pathways and intracellular signaling enzymes.

Each peer-reviewed entry consists of an easy-to-read and up-to-date overview of the available information in the area, as well as a list of key references to guide both the new investigator and the experienced researcher in their searches and reviews of the current literature. Each entry includes a table that presents the currently accepted classification of a given receptor, ion channel, enzyme or transporter into its component subtypes and subgroups. In addition, a variety of information is provided on structure, selective agonists, selective antagonists, signal transduction mechanisms, and radioligands of choice, plus information on tissue expression, physiological function and disease relevance.

This Handbook was made possible with the support of over 220 contributing authors and reviewers located in 19 countries. We gratefully acknowledge their outstanding efforts in writing, updating and reviewing the entries, and recognize the supportive advice from Professors Philip Cohen and Tony Hunter for the selection of the more than 30 kinase and phosphatase entries.

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