4-Carboxytrityl Resins

ChemFiles Volume 3 Article 4

PRODUCTS: 00481, 75040


4-Carboxytrityl resin, prepared by acylation of aminomethylpolystyrene with 4-carboxytrityl handle, has been described to offer high acid lability similar to 2-chlorotrityl resin.[1-3] This trityl alcohol resin has to be converted to the chloride form directly before loading the first residue by employing AcCl or SOCl2 in toluene. For detailed information about applications, attachment of the C-terminal amino acid and cleavage conditions, please look at the references cited for 2-chlorotrityl chloride resin 26568.

HypoGel® 200 Trt-OH resin is derived from HypoGel® 200 NH2 by acylation with highly acid labile 4-carboxytrityl handle.[4-6] Before use the resin has to be converted to the chloride form using AcCl or SOCl2 in toluene. For detailed information about applications, attachment of the C-terminal amino acid and cleavage conditions, please take a look at the references cited for resin 00481 and 2-chlorotrityl chloride resin 26568.

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Materials

     

References

  1. Bayer E. et al. Peptides, Chemistry, Structure and Biology, Proc. 13th Am. Pept. Symp., Hodges, R. S., Smith, J. A., Eds: ESCOM, Leiden 1994; p. 156
  2. Grübler G. et al. Innovations and Perspectives in solid-phase Synthesis, 3rd International Symposium, (R. Epton, ed.), Mayflower Worldwide, Birmingham 1994; p. 517.
  3. Henkel, B. et al. Z. Naturforsch B, 1996, 51, 1339.

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