Discover Reagents for Selective Metalations and Additions from Sigma-Aldrich

By: William Sommer, Aldrich ChemFiles 2009, 9.6, 11.

TurboGrignards for Hal/Mg Exchange of Aryl and Heteroaryl Compounds

  • Increased functional group compatibility
  • Mild reaction conditions
  • Side reactions inhibited

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Knochel-Hauser-Base for Selective Deprotonations

  • Improved reactivity and basicity
  • Increased functional group compatibility
  • Mild reaction conditions
  • Side reactions inhibited
  • Excellent solubility in THF

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Selective 1,2-Additions

  • Enolizable and sterically hindered ketones
  • Low H2O content and THF-soluble
  • Decrease in side products

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Materials

     
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