Hoveyda-Snapper Catalyst For Desymmetrization Of meso-Diols

Aldrich ChemFiles 2007, 7.3, 9.

Aldrich ChemFiles 2007, 7.3, 9.

 Professors Marc Snapper and Amir Hoveyda at Boston College have recently reported1 the development of an amino-acid-based small molecule 1 capable of promoting asymmetric monosilylation of meso-1,2-diols. The catalyst is compatible with a variety of silyl chlorides and generally provides enantioselectivities above 88%, and the reactions do not require rigorous exclusion of air or moisture. Furthermore, the catalyst can be easily recovered in near-quantitative yield after use and subsequently reused with identical efficiency. This catalyst greatly increases the efficiency with which optically-enriched molecules can be prepared.

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Materials

     

References

  1. Zhao, Y. et al. Nature 2006, 443, 67.

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