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Ishikawa’s Reagent

Chemfiles Volume 5 Article 1

Ishikawa’s reagent (N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine) has also demonstrated utility in fluorination. In a recent example, Ishikawa’s reagent has been used in a clean and reproducible fluorination protocol on an intermediate in the total synthesis of 26-fluoroepothilone B(Scheme 14)1

Scheme 14

Ishikawa’s reagent also displays the ability to insert a fluoro(trifluoro-methyl)methylene moiety in unsaturated alcohols(Scheme 15).2


Scheme 15

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  1. Koch, G. et al. Synlett. 2004, 693.
  2. Ogu, K-i. et al. Tetrahedron Lett. 1998, 39, 305.

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