MeO-BIPHEP

chemfiles volume 5 article 4

With Ru-complexes of this atropisomeric diphosphine ligand, b-keto esters are reduced to their corresponding b-hydroxy esters in high enantioselectivities. Selected results are shown in Scheme 13.


Scheme 13

Further enantioselective transformations of the MeO-BIPHEP ligands include Rh(I)-catalyzed asymmetric isomerizations of allylamines to enamines1 and Pd(0) complexes for cyclizations of hydroxy allylic carbonates.2

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References

  1. Schmid, R. et al. Helv. Chim. Acta 1991, 74, 370.
  2. Labrosse, J.-R. et al. Tetrahedron: Asymmetry 1999, 10, 1069.

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