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MIDA Boronates for Classically Challenging Suzuki-Miyaura Cross-Couplings

By: Aaron Thornton, Chemfiles Volume 11 Article 1

The power of this slow-release concept has been further illustrated by utilizing various MIDA boronates of which the corresponding boronic acids have historically exhibited challenges with respect to either storage or use, including 2-heterocyclic, vinyl and cyclopropyl boronic acids. Because these organoboron species readily decompose through a variety of pathways, the efficiency with which their corresponding MIDA boronates may be coupled is particularily noteworthy (Table 1).

Table 1: Slow-release cross-coupling of MIDA boronates with historically challenging substrates.

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