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Nucleophilic Additions to Allenes

By: William Sommer, chemfiles volume 9 article 5

Allenes are functional groups possessing a 1,2-diene moiety. They can serve as precursors in the synthesis of highly complex and strained target molecules of industrial and biological importance. The reactivity is unique as it is spread over three contiguous carbon atoms and it has been successfully applied to many fields such as pharmaceutical, dyes or polymers.1 However, allenes are challenging substrates due to the different factors that contribute to the reaction such as chemoselectivity, regioselectivity, and diastereoselectivity.

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  1. Hashmi, A. S. K. Angew. Chem., Int. Ed. Engl. 2000, 39, 3590
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