Potassium Cyclopropyltrifluoroborate

Chemfiles Volume 7 Article 3

Cyclopropyl groups are found in a variety of natural products and are increasingly incorporated into pharmaceuticals such as the broad-spectrum antibiotic ciprofloxacin. Both the Charette1 and Deng2 groups have reported success in the cross-coupling of potassium cyclopropyltrifluoroborates with aryl bromides in the presence of common palladium catalysts. The trifluoroborate salts exhibit enhanced stability and more certain stoichiometry relative to their boronic acid counterparts. However, like boronic acids, post-reaction byproducts are easily removed. We are pleased to add this useful reagent to our ever-growing portfolio of organoboron compounds.

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References

  1. Charette, A. B. et al. Synlett 2005, 11, 1779.
  2. Fang, G.-H. et al. Org. Lett. 2004, 6, 357.

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