Pure Solv™ Micro Solvent Purification Systems Easy Access to Freshly Prepared Anhydrous Solvents

By: Paula Freemantle, Chemfiles Volume 10 Article 1

        Paula Freemantle

Paula Freemantle
Product Manager
Email:labware@sial.com

Many organic and organometallic reactions require solvents that are free of water and oxygen. Classically, the anhydrous solvents are prepared in the laboratory by refluxing the solvent in the presence of an active metal. This is an intrinsically hazardous operation.

The dangers of this method of solvent purification led Professor Robert Grubbs to investigate alternative methods. In collaboration with Dow, Grubbs published a method to remove water from organic solvents using activated alumina [Organometallics, 15 1558 (1996)].

This approach uses dry nitrogen or argon to push solvent at ambient temperature through a column containing the drying agent. Oxygen is removed by bubbling inert gas through the solvent reservoir prior to pushing it through the drying column.

Pure Solv Micro is a bench scale, self-contained system that permits the easy dispensing of small quantities of dry solvent at the turn of a valve. These systems are engineered for safety because they operate at very low pressure, require no electricity, and are bonded and grounded to remove hazards associated with electrostatic discharge.

Pure Solv Diagram

Pure Solv Diagram


How Pure Solv Micro Works

  1. Fill the stainless steel solvent storage reservoir with 4 L of HPLC-grade raw solvent.
  2. Degas the solvent by connecting the nitrogen line to the reservoir.
  3. Pressurize the solvent reservoir to push solvent through the drying column.
  4. Dry solvent is stored inside the drying column ready for immediate use.
  5. Attach a collection flask to the dispensing joint.
  6. Degas the collection flask using vacuum and inert gas cycling.
  7. Turn the dispense valve to allow solvent to flow into the collection flask.
  8. Refill the flask with inert gas.
  9. Your collected solvent is now ready to use.

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Materials

     
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