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Rink Acid Resins

ChemFiles Volume 3 Article 4

Rink acid resins are extremely acid-sensitive supports. Protected peptide acid fragments can be obtained without any loss of sidechain protection functionality by applying 10% acetic acid in dichloromethane. Consecutive coupling steps during chain elongation should be carried out under basic conditions to prevent any premature cleavage of peptide chains.

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  1. Rink, H., Tetrahedron Lett. 1987, 28, 3787.

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