Schaus MBH Catalyst

Aldrich ChemFiles 2006, 6.4, 13.

Aldrich ChemFiles 2006, 6.4, 13.

A highly enantioselective addition of cyclohexenone to different aldehydes (asymmetric Morita–Baylis–Hillman reaction) catalyzed by octahydro-BINOL-derived Brønsted acid (669172) was reported by Schaus (Scheme 15). Important for achieving high enantioselectivity were both the partial saturation and substitution at the 3,3’-positions of the BINOL derivative.1


Scheme 15.

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Materials

     

References

  1. McDougal, N. T.; Schaus, S. E. J. Am. Chem. Soc. 2003, 125, 12094.

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