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Suzuki Coupling

By: Josephine Nakhla, Chemfiles Volume 10 Article 4

Josephine Nakhla,Ph.D.
Market Segment Manager
Organometallics & Catalysis
josephine.nakhla@sial.com

Suzuki Coupling The cross-coupling of organoborons with organic electrophiles in the presence of a palladium catalyst (Scheme 1), is one of the most widely utilized methods for C –C bond formation in transition metal chemistry. Organoboron reagents are readily prepared or are commercially available, relatively non-toxic, and do not react with common functional groups. Several new product additions to our boron portfolio are highlighted below.

Scheme 1: The Suzuki reaction

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References

  1. Wolfe, J. P.; Nakhla, J. S. The Suzuki Reaction. Name Reactions for Homologations. John Wiley & Sons, Inc. (2009), (Pt. 1), 163–184.

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