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Trityl Resins

ChemFiles Volume 3 Article 4

PRODUCTS: 93003, 69516, 65374

 

Trityl chloride resins and as 4-methyl- and 4-methoxytrityl derivatives render increased acid lability, making them less favorable for stable attachment of C-terminal carboxylic acid during peptide synthesis.(1)  In SPPS and SPOS, the immobilization of other functionalities like amines, alcohols, hydroxylamines, hydrazines, or thiols are described; e.g. N-α-amino groups and N-ε-amino groups of lysine are used in anchoring protected peptide segments.(2)

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Materials

     

References

  1. Barlos, K. et al. Tetrahedron Lett. 1989, 30, 3943.
  2. Barlos, K. et al. Peptides 1992, Proc. 23rd Eur. Pept. Symp. C. H. Schneider, A. N. Eberle, Eds, ESCOM: Leiden 1993; p. 281.

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