Efficient Pd-Catalyzed Amination Reactions for Heterocycle Functionalization

Reaction Scheme

Abstract

The Pd-catalyzed amination of unprotected benzo-fused heterocycles is reported, which allows for greater flexibility and efficiency in the modification of this important class of molecules. The generality of these simple and efficient procedures is demonstrated through the synthesis of a wide variety of structural types.

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Procedure

A screw-cap test-tube, equipped with a magnetic stir bar,?was charged with RuPhos (L1) (2.3 mg, 1 mol %) and?RuPhos precatalyst

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