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Janis Louie Group – Professor Product Portal

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Professor Janis Louie

Professor Louie's research focuses on the discovery and mechanistic understanding of new reactions catalyzed by transition metal complexes.  She has developed a highly active Ni(0) catalyst that effectively mediates a variety of cycloaddition and isomerization reactions.  For example, her group developed a series of Ni(0) catalysts that mediate the cycloaddition between unsaturated hydrocarbons (e.g. diynes, enynes, alkynes) and heterocumulenes (such as CO2 and isocyanates) as well as other derivatives (such as aldehydes, ketones, nitriles, azetidinones) to afford a variety of substituted heterocycles.  The Ni catalyzed coupling of an alkyne and an azetidinone affords 3-piperidones, a N-heterocyclic building block that is difficult to make by traditional methods.

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Puneet Kumar and Janis Louie
Organic Letters, 14(8), 2026-2029 (2012)
An easy and expeditious route to substituted piperidines is described. A Ni-phosphine complex was used as catalyst for [4 + 2] cycloaddition of 3-azetidinone and alkynes. The reaction has broad substrate scope and affords piperidines in excellent yi....Read More
Ryan M Stolley et. al
Journal of the American Chemical Society, 134(36), 15154-15162 (2012)
The reaction of Ni(COD)(2), IPr, and nitrile affords dimeric [Ni(IPr)RCN](2) in high yields. X-ray analysis revealed these species display simultaneous ?(1)- and ?(2)-nitrile binding modes. These dimers are catalytically competent in the formation o....Read More
Puneet Kumar et. al
Angewandte Chemie (International Edition), 51(34), 8602-8606 (2012)
A cool break: 3-Azetidinone and a variety of diynes undergo a cycloaddition reaction catalyzed by Ni/IPr to give dihydroazocine compounds (see scheme; IPr=1,3-bis(2,6-diisopropylphenyl)imidazolidene). The reaction involves a challenging C(sp)2-C(sp)....Read More
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