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Neil Garg Group - Professor Product Portal

Professor Product Portal Index

Professor Neil Garg

 

The Garg group develops methods for the synthesis of natural products and pharmaceuticals.  One key method pertains to heterocyclic arynes, such as indolynes and pyridynes, which are generated in situ from silyltriflate precursors under mild fluoride based reaction conditions. Heterocyclic arynes can be trapped by a variety of reagents (e.g., nucleophiles and cycloaddition partners) to prepare diverse libraries of substituted heterocycles from common precursors. The Garg lab has also collaborated with Prof. Ken Houk to develop the aryne distortion model, which in turn allows chemists to predict regioselectivity in reactions of unsymmetrical arynes.

Garg Group website

Link to Aldrichimica Acta 47(2) review (2014)

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For recent articles from the Garg Laboratory:

Products available at Aldrich from the Garg Laboratory

     

Adam E Goetz, Neil K Garg
Nature Chemistry 2013-01-01
The pyridine heterocycle continues to play a vital role in the development of human medicines. More than 100 currently marketed drugs contain this privileged unit, which remains highly sought after synthetically. We report an efficient means to access di- and trisubstituted pyridines in an efficient and highly controlled manner ...Read More
G-Yoon J Im, Sarah M Bronner, Adam E Goetz, Robert S Paton, Paul H-Y Cheong, K N Houk, Neil K Garg
Journal of the American Chemical Society 2010-12-22
Efficient syntheses of 4,5-, 5,6-, and 6,7-indolyne precursors beginning from commercially available hydroxyindole derivatives are reported. The synthetic routes are versatile and allow access to indolyne precursors that remain unsubstituted on the pyrrole ring. Indolynes can be generated under mild fluoride-mediated conditions,...Read More
Tehetena Mesganaw, G-Yoon J Im, Neil K Garg
Journal of Organic Chemistry 2013-04-05
A mild and operationally simple method to synthesize diphenylhexatriene (DPH) is reported. The method relies on the Pd-catalyzed dimerization of cinnamyl acetate and provides efficient access to DPH in a single step.Read More