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Stradiotto Group – Professor Product Portal

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Professor Mark Stradiotto

The main focus of the Stradiotto group has centered on the development and application of novel electronically rich, sterically encumbered P,N-based ancillary ligands for use in late metal catalysis, including Pd and Au chemistry. To this end, the Stradiotto group has developed the DalPhos series of ligands, of which Me-DalPhos (751413) and Mor-DalPhos (751618) in particular have led to considerable improvements in ubiquitous and/or challenging catalytic transformations, including the Buchwald-Hartwig Amination reaction and alkyne hydroamination. The DalPhos ligands not only engage classically difficult reaction partners (often at ambient temperature) but have also been applied successfully to a variety of synthetic challenges, such as the monoarylation of ammonia, hydrazine, and acetone. The Stradiotto group also established the applicability of the DalPhos ligand class in Au-catalyzed hydroamination chemistry involving challenging reaction pairings including the addition of secondary dialkylamines to internal alkynes; indeed Au-based DalPhos products are also available from Sigma-Aldrich.

Landmark publications and the latest developments from the Stradiotto group are accessible through the links provided below. For further examples of the versatility of the DalPhos ligands developed by the Stradiotto group, please also refer to the Liming Zhang Professor Portal.

Stradiotto Group website
Link to Aldrichimica Acta review (2012)

For recent articles from the Stradiotto Laboratory

Products available at Aldrich from the Stradiotto Laboratory

     

Kevin D Hesp, Mark Stradiotto
Journal of the American Chemical Society 2010-12-29
We report the use of a P,N-ligand to support a gold complex as a state-of-the-art precatalyst for the stereoselective hydroamination of internal aryl alkynes with dialkylamines to afford E-enamine products. Substrates featuring a diverse range of functional groups on both the amine (ether, sulfide, N-Boc amine, fluoro, nitrile, ...Read More
Rylan J Lundgren, Brendan D Peters, Pamela G Alsabeh, Mark Stradiotto
Angewandte Chemie. International edition in English 2010-06-01
Kevin D Hesp, Rylan J Lundgren, Mark Stradiotto
Journal of the American Chemical Society 2011-04-13
We report the first example of selective Pd-catalyzed mono-α-arylation of acetone employing aryl chlorides, bromides, iodides, and tosylates. The use of appropriately designed P,N-ligands proved to be the key to controlling the reactivity and selectivity. The reaction affords good yields with substrates containing a range of fun...Read More