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Your Materials Matter

By: Joe Porwoll, Material Matters Volume 3 Issue 3

Joe Porwoll, President Aldrich Chemical Co., Inc.

Do you have a compound that you wish Sigma-Aldrich® could list to help materials research? If it is needed to accelerate your research, it matters—please send your suggestion to matsci@sial.com and we will be happy to give it careful consideration.

N-Hydroxyethyl acrylamide — Tool for Lab-On-A-Chip Research

Professor Annelise Barron of Stanford University kindly suggested that we offer N-hydroxyethyl acrylamide (HEAA), a monomer which can be used to make polymers that are useful as wall coatings and separation media for lab-on-achip devices. Hydrophilic poly-N-hydroxyacrylamide (pHEAA), synthesized by free radical polymerization of HEAA in water, forms a stable adsorbed coating on glass and fused silica microchannels, enabling excellent biomolecule separations. pHEAA coatings eliminate electroosmotic flow and greatly reduce non-specifc adsorption of biomolecules to the internal walls of microfluidic channels. DNA fragments of > 500 bases have been successfully separated and sequenced using pHEAA-assisted microcapillary electrophoresis.1,2

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References

  1. Albarghouthi, M.N., Buchholtz, B.A., Huiberts, P.J., Stein, T.M., Barron, A.E. Electrophoresis 2002, 23, 1429.
  2. Fredlake, C.P., Hert, D.G., Kan, C.W., Chiesl, T.N., Root, B.E., Forster, R.E., Barron, A.E. Proc. Natl. Acad. Sci. USA 2008, 105, 476.

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