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Privileged structures are a class of molecules that are capable of binding to multiple receptors with high affinity. In order to be considered privileged, a substructure should represent a molecule’s core element and make up a significant portion of its total mass. Recent reports1,2,3 have shown the presence of the arylpiperazine scaffold in potent and selective agonists of the human melanocortin-4 receptor (Fig 1).


Fig. 1


Sigma-Aldrich is proud to offer the following new BOC-protected arylpiperazines to our organic synthesis and drug discovery customers.


  1. Richardson, T. I. et al. J. Med. Chem. 2004, 47, 744.
  2. Pontillo, J. et al. Bioorg. Med. Chem. Lett. 2004, 14, 4417.
  3. Dyck, B. et al. Bioorg. Med. Chem. Lett. 2003, 13, 3793.

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