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Y0001263

Etacrynic acid for system suitability

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
Ethacrynic acid, (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid
Empirical Formula (Hill Notation):
C13H12Cl2O4
CAS Number:
Molecular Weight:
303.14
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

etacrynic acid

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O

InChI

1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)

InChI key

AVOLMBLBETYQHX-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Etacrynic acid for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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[Clinical pharmacology of diuretics with special reference to furosemide and ethacrynic acid].
J Prandota
Postepy higieny i medycyny doswiadczalnej, 34(1), 47-74 (1980-01-01)
Ethacrynic acid and related diuretics: relationship of structure to beneficial and detrimental actions.
D A Koechel
Annual review of pharmacology and toxicology, 21, 265-293 (1981-01-01)
[Ethacrynic acid].
G C Urbinati
La Clinica terapeutica, 37(4), 350-369 (1966-05-31)
J H Ploemen et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(8), 913-923 (1993-08-01)
1. The diuretic drug ethacrynic acid (EA) is a potent reversible inhibitor of rat and human glutathione S-transferases (GST), with I50-values (microM) of 4.6-6.0, 0.3-1.9 and 3.3-4.8 for alpha, mu and pi-class, respectively. 2. The reversible inhibition by the glutathione
Toxicity of ethacrynic acid and furosemide.
L B Cooperman et al.
American heart journal, 85(6), 831-834 (1973-06-01)

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