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Showing 1-30 of 592 results for "431311" within Papers
Benedikt Warth et al.
Journal of chromatography. A, 1423, 183-189 (2015-11-12)
Nucleotide sugars, the activated forms of monosaccharides, are important metabolites involved in a multitude of cellular processes including glycosylation of xenobiotics. Especially in plants, UDP-glucose is one of the most prominent members among these nucleotide-sugars, as it is involved in
I Zabaleta et al.
Journal of chromatography. A, 1387, 13-23 (2015-02-25)
An analytical method for the simultaneous determination in fish liver and muscle tissue and mussel samples of 14 perfluorinated compounds (PFCs), including three perfluoroalkylsulfonates (PFSAs), seven perfluorocarboxylic acids (PFCAs), three perfluorophosphonic acids (PFPAs) and perfluorooctanesulfonamide (PFOSA), and 10 potential precursors
Sara Castiglioni et al.
Journal of hazardous materials, 282, 51-60 (2014-07-06)
Perfluorinated substances are listed among emerging contaminants because they are globally distributed, environmentally persistent, bioaccumulative and potentially harmful. In a three-year monitoring campaign (2010-2013) we investigated the occurrence, sources and fate of nine perfluoroalkylcarboxylic acids and three perfluoroalkylsulfonic acids, in
Timothy M Allison et al.
Nature communications, 6, 8551-8551 (2015-10-07)
The effects of protein-ligand interactions on protein stability are typically monitored by a number of established solution-phase assays. Few translate readily to membrane proteins. We have developed an ion-mobility mass spectrometry approach, which discerns ligand binding to both soluble and
Kuniko Mitamura et al.
Steroids, 85, 18-29 (2014-04-12)
A liquid chromatography (LC)/electrospray ionization (ESI)-mass spectrometry (MS) method for the direct determination of eighteen tetrahydrocorticosteroid sulfates in human urine has been developed. The analytes were 3- and 21-monosulfates and 3,21-disulfates of tetrahydrocortisol (THF), tetrahydrocortisone (THE), tetrahydro-11-deoxycortisol (THS), and their
Oskar Vilhelmsson-Timmermand et al.
Nuclear medicine and biology, 42(4), 375-380 (2015-01-13)
Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects
Robert Jirásko et al.
Analytical and bioanalytical chemistry, 406(19), 4601-4610 (2014-05-21)
The combination of ultrahigh-resolution mass spectrometry imaging (UHRMSI) and ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC/MS/MS) was used for the identification and the spatial localization of atorvastatin (AT) and its metabolites in rat tissues. Ultrahigh-resolution and high mass
Jian-Sheng Liu et al.
International journal of nanomedicine, 9, 3923-3935 (2014-08-26)
P-glycoprotein (P-gp) mediated drug efflux across the blood-brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targeted delivery of AEDs. However, their
Jessica Oenarto et al.
Archives of biochemistry and biophysics, 560, 59-72 (2014-07-09)
This study characterizes the expression of the osmolyte transporters betaine/γ-amino-n-butyric acid (GABA) transporter (BGT-1), the taurine transporter (TauT) and the sodium-dependent myo-inositol transporter (SMIT) in various rat brain cells in culture and in rat and human cerebral cortex in situ.
Yu Zhang et al.
Environmental science and pollution research international, 21(16), 9468-9476 (2013-08-15)
Nonylphenol ethoxylates (NPEOs) with low ethoxylation degree (NPav₂EO; containing two ethoxy units on average) and estrogenic properties are the intermediate products of nonionic surfactant NPEOs. To better understand the environmental fate of low-ethoxylated NPEOs, phylogenetically diverse low-ethoxylated NPEO-degrading bacteria were
Morten Persson et al.
Molecular pharmaceutics, 11(8), 2796-2806 (2014-06-24)
The urokinase-type plasminogen activator receptor (uPAR) is implicated in cancer invasion and metastatic development in prostate cancer and provides therefore an attractive molecular target for both imaging and therapy. In this study, we provide the first in vivo data on
Limei Chang et al.
Plant physiology, 169(2), 1127-1140 (2015-08-25)
Transcriptome resources for the medicinal plant Glaucium flavum were searched for orthologs showing identity with characterized O-methyltransferases (OMTs) involved in benzylisoquinoline alkaloid biosynthesis. Seven recombinant proteins were functionally tested using the signature alkaloid substrates for six OMTs: norlaudanosoline 6-OMT, 6-O-methyllaudanosoline
Haidy Metwally et al.
Analytical chemistry, 87(4), 2434-2442 (2015-01-17)
Protein analyses by electrospray ionization (ESI) mass spectrometry can suffer from interferences caused by nonvolatile salts. The mechanistic basis of this effect remains to be fully investigated. In the current work we explore the behavior of proteins under native and
Hua Zhang et al.
Analytical chemistry, 87(5), 2878-2883 (2015-02-14)
Characterization of enzymatic reactions occurring in untreated biological samples is of increasing interest. Herein, the chemical conversion of alliin to allicin, catalyzed by allinase, in raw garlic cloves has been followed in vivo by internal extractive electrospray ionization mass spectrometry
Sebastiaan Bijttebier et al.
Food chemistry, 165, 371-378 (2014-07-21)
Food processing enterprises produce enormous amounts of organic waste that contains valuable phytochemicals (e.g. C17-polyacetylenes). Knowledge on the phytochemicals content is a first step towards valorisation. Quantification of C17-polyacetylenes is however often hampered by the lack of commercially available standards
DABCO as a mild and efficient catalytic system for the synthesis of highly substituted imidazoles via multi-component condensation strategy.
Murthy SN, et al.
Tetrahedron Letters, 51(40), 5252-5257 (2010)
Shuai Zhang et al.
Analytical and bioanalytical chemistry, 407(30), 8971-8977 (2015-10-03)
Reliably detecting nitrofurazone (NFZ) residues in farmed crab and shrimp was previously hindered by lack of appropriately specific analytical methodology. Parent NFZ rapidly breaks down in meat, and the commonly used side-chain metabolite, semicarbazide (SEM), is non-specific as it occurs
Marcello Locatelli et al.
Journal of chromatography. A, 1388, 79-86 (2015-02-24)
This paper reports the validation of a quantitative high performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous analysis, in mouse plasma, of eperisone hydrochloride and paracetamol by protein precipitation using zinc sulphate-methanol-acetonitrile. The analytes were resolved on a Gemini
Francesca Giuffrida et al.
Lipids, 49(10), 997-1004 (2014-09-05)
It has been reported that dietary gangliosides may have an important role in preventing infections and in brain development during early infancy. However, data related to the evolution of their concentration over the different stages of lactation are scarce. Liquid
Miina Ruokolainen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 65, 45-55 (2014-09-16)
The aim of this study was to investigate the feasibility of titanium dioxide (TiO2) photocatalysis for oxidation of anabolic steroids and for imitation of their phase I metabolism. The photocatalytic reaction products of five anabolic steroids were compared to their
Sifei Han et al.
Pharmaceutical research, 32(5), 1830-1844 (2014-12-03)
Recent studies have demonstrated the potential for a triglyceride (TG) mimetic prodrug to promote the delivery of mycophenolic acid (MPA) to the lymphatic system. Here, the metabolic pathways that facilitate the lymphatic transport of the TG prodrug (1,3-dipalmitoyl-2-mycophenoloyl glycerol, 2-MPA-TG)
Dominic J Hare et al.
ACS chemical neuroscience, 6(3), 398-402 (2015-01-15)
Plasma iron levels are decreased in Alzheimer's disease (AD) and associated with an idiopathic anemia. We examined iron-binding plasma proteins from AD patients and healthy controls from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing using size
Tõiv Haljasorg et al.
Journal of agricultural and food chemistry, 62(23), 5259-5268 (2014-05-23)
A wide range of anthropogenic pollutants that possess serious environmental and health risks are known. One type of these harmful substances that have become a focus of interest during the past decade are perfluoroalkyl acids (PFAAs), which are extensively used
J Y Liew et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 25(3), 274-279 (2015-02-03)
To investigate the association between vitamin D levels, angiographic severity of coronary artery disease, arterial stiffness and degree of peripheral arterial disease (PAD) as assessed by ankle brachial index (ABI). 375 patients undergoing coronary angiography from November 2012 to September
Nicola Mastroianni et al.
Journal of chromatography. A, 1360, 93-99 (2014-08-12)
The increasing, generalized consumption of alcohol, especially among young people, generates great concern in our society due to its negative consequences on public health and safety. Besides the traditional, official methods employed for estimation of alcohol consumption, the monitoring of
Ahlam Alalwiat et al.
The Analyst, 140(22), 7550-7564 (2015-10-16)
A multidimensional mass spectrometry (MS) methodology is introduced for the molecular level characterization of polymer-peptide (or polymer-protein) copolymers that cannot be crystallized or chromatographically purified. It encompasses electrospray ionization (ESI) or matrix-assisted laser desorption ionization (MALDI) coupled with mass analysis
Alberto Sánchez-Guijo et al.
Journal of lipid research, 56(2), 403-412 (2014-12-17)
Steroid sulfatase (STS) deficiency is the underlying cause of the skin condition known as recessive X-linked ichthyosis (RXLI). RXLI patients show scales on their skin caused by high concentrations of cholesterol sulfate (CS), as they are not capable of releasing
Walid M Ebeid et al.
Analytical and bioanalytical chemistry, 406(26), 6701-6712 (2014-09-06)
A RP-LC method was developed and validated for simultaneous determination of the active components, azilsartan medoxomil (AZL) and chlorthalidone (CLT), in their novel antihypertensive combined recipe. The chromatographic separation was achieved on an Eclipse XDB-C18 (4.6 × 150 mm, 5 μm) column using a mobile
Jérôme Devoy et al.
Journal of occupational and environmental hygiene, 16(3), 229-241 (2018-12-21)
Beryllium (Be) is a metal mainly used in the form of alloys, with copper (Cu) and aluminium (Al) in the metal industry. Be is an extremely toxic element which must be handled under strictly controlled conditions to avoid health hazards
Sophie Lissalde et al.
The Science of the total environment, 488-489, 188-196 (2014-05-17)
This study focuses on how Polar Organic Chemical Integrative Samplers (POCIS) work in real environmental conditions. A selection of 23 polar pesticides and 8 metabolites were investigated by exposure of triplicates of integrative samplers in two rivers in France for
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