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Showing 1-30 of 1763 results for "695076" within Papers
Rick Kapur et al.
British journal of haematology, 166(6), 936-945 (2014-06-10)
Haemolytic disease of the fetus and newborn (HDFN) may occur when maternal IgG antibodies against red blood cells (RBCs), often anti-RhD (anti-D) antibodies, cross the placenta and mediate the destruction of RBCs via phagocytic IgG-Fc-receptors (FcĪ³R). Clinical severity is not
Ping Xiang et al.
Biomaterials, 35(37), 9777-9788 (2014-09-16)
Various artificial membranes have been used as scaffolds for retinal pigment epithelium cells (RPE) for monolayer reconstruction, however, long-term cell viability and functionality are still largely unknown. This study aimed to construct an ultrathin porous nanofibrous film to mimic Bruch's
Rodrigo S Reis et al.
Journal of proteome research, 14(11), 4743-4751 (2015-09-22)
Plant microRNAs (miRNAs) operate by guiding the cleavage or translational inhibition of mRNA targets. They act as key gene regulators for development and environmental adaptation, and Dicer-partnering proteins DRB1 and DRB2 govern which form of regulation plays the dominant role.
P Kiousi et al.
Journal of mass spectrometry : JMS, 50(12), 1409-1419 (2015-12-05)
This manuscript describes the direct detection of mesteroloe sulfo-conjugated metabolites by liquid chromatography/quadrupole/time of flight mass spectrometry (LC/Q/TOFMS) with special focus on evaluation of their retrospective detectability and their structure elucidation. A comparison of their long-term detectability, with the mesterolone
Sae Young Lee et al.
PloS one, 10(4), e0123306-e0123306 (2015-04-10)
Hypertriglyceridemia (HTG) is a risk factor for atherosclerotic cardiovascular disease (CVD). We investigated alterations in plasma metabolites associated with borderline-to-moderate HTG (triglycerides (TG) 150-500 mg/dL). Using UPLC-LTQ-Orbitrap mass spectrometry analysis, the metabolomics profiles of 111 non-diabetic and non-obese individuals with
Soo Hyeon Bae et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(12), 1099-1107 (2014-06-17)
1. BST204, a purified ginseng dry extract containing a high concentration of racemic Rh2 and Rg3 mixtures, is being developed for supportive care use in cancer patients in Korea. This study investigates the pharmacokinetics and tissue distribution of BST204 in
Jun Cheng et al.
Food chemistry, 168, 90-99 (2014-08-31)
The aim of this study was to investigate the applicability of artificial neural network (ANN) and multiple linear regression (MLR) models for the estimation of acrylamide reduction by flavonoids, using multiple antioxidant capacities of Maillard reaction products as variables via
Sonam Vijay et al.
PloS one, 10(3), e0119666-e0119666 (2015-03-06)
Vector control is one of the major global strategies for control of malaria. However, the major obstacle for vector control is the development of multiple resistances to organochlorine, organophosphorus insecticides and pyrethroids that are currently being used in public health
Yetrib Hathout et al.
Human molecular genetics, 23(24), 6458-6469 (2014-07-17)
It is expected that serum protein biomarkers in Duchenne muscular dystrophy (DMD) will reflect disease pathogenesis, progression and aid future therapy developments. Here, we describe use of quantitative in vivo stable isotope labeling in mammals to accurately compare serum proteomes
Ning-fang Cai et al.
Acta pharmacologica Sinica, 35(11), 1447-1452 (2014-10-07)
Pharmacodynamic analysis of intravenous recombinant urate oxidase produced by Escherichia coli was performed in healthy subjects using a pharmacokinetic/pharmacodynamic (PK/PD) model. A randomized, single-blind, placebo-controlled study was performed in 40 healthy Chinese subjects (4 groups of 10 subjects each, placebo
Yogini Jaiswal et al.
Phytochemical analysis : PCA, 25(6), 514-528 (2014-04-17)
Asparagus is esteemed in Traditional Chinese Medicine and Ayurveda, and it is commercially one of the most important drugs in the global herbal market. Comparative metabolite profiling of different species would help in determining the similarities and ascertain their validity
Natalie Kummer et al.
Journal of analytical toxicology, 39(1), 17-23 (2014-10-03)
The Society of Hair Testing (SoHT) has provided cutoffs for the quantification of ethyl glucuronide (EtG) in hair to indicate occasional or chronic/excessive alcohol consumption. Although several sensitive methods have been reported, past proficiency test results show a lack of
Dong-Woon Cho et al.
Archives of pharmacal research, 37(9), 1159-1168 (2014-01-22)
Fermentation of natural products is emerging as an important processing method and is attracting a lot of attention because it may have the advantage of having a new biological function. In this study, fruits of Opuntia ficus-indica were enzymatically hydrolyzed
Simona De Gregori et al.
Therapeutic drug monitoring, 36(3), 335-344 (2014-03-07)
Pain is one of the most prevalent and distressing symptoms in patients with cancer. There is evidence from observational studies that many patients do not get adequate relief. Although data in the literature confirm the effectiveness of most opioid drugs
Arash Mirzahosseini et al.
Journal of pharmaceutical and biomedical analysis, 107, 209-216 (2015-01-17)
The site-specific acid-base properties of ovothiol A disulfide (OvSSOv), the smallest hexabasic multifunctional biomolecule with complex interdependent moieties, were studied with (1)H NMR-pH and potentiometric titrations. The unprecedented complexity of the protonation microequilibria could be overcome by taking into account
Dorien Van den Bossche et al.
Clinical biochemistry, 47(15), 112-115 (2014-07-09)
Liquid chromatography tandem mass spectrometry has become increasingly popular in clinical laboratories over the last decade due to the inherent sensitivity and specificity of the technology. Nevertheless, full automation and hence application in routine laboratories is still hampered by laborious
Jess Morhayim et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 274-285 (2014-11-02)
Beyond forming bone, osteoblasts play pivotal roles in various biologic processes, including hematopoiesis and bone metastasis. Extracellular vesicles (EVs) have been implicated in intercellular communication via transfer of proteins and nucleic acids between cells. We focused on the proteomic characterization
Sandeep Tyagi et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(3), 869-874 (2015-01-07)
A key drug for the treatment of leprosy, clofazimine has recently been associated with highly effective and significantly shortened regimens for the treatment of multidrug-resistant tuberculosis (TB). Consequently, we hypothesized that clofazimine may also shorten the duration of treatment for
Silvia Angeletti et al.
PloS one, 10(3), e0120502-e0120502 (2015-03-18)
Viridans Group Streptococci (VGS) species-level identification is fundamental for patients management. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been used for VGS identification but discrimination within the Mitis group resulted difficult. In this study, VGS identifications
Imen Lassoued et al.
Journal of proteomics, 128, 8-17 (2015-07-08)
Thornback ray skin gelatin has been hydrolyzed with two different proteases in order to obtain peptides with ACE inhibitory and antioxidant activity. Hydrolysates with protease from Bacillus subtilis A26 (TRGH-A26) displayed ACE inhibitory activity with an IC50 value of 0.94
Takahiro Takayama et al.
Analytica chimica acta, 898, 73-84 (2015-11-04)
Chiral metabolites are found in a wide variety of living organisms and some of them are understood to be physiologically active compounds and biomarkers. However, the overall analysis of chiral metabolomics is quite difficult due to the high number of
Noel Kong et al.
Journal of separation science, 37(21), 3015-3023 (2014-08-22)
A sensitive hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry method was developed and validated for the simultaneous detection and quantification of etilefrine and oxilofrine in equine blood plasma and urine. The method is highly sensitive and specific with
Milica Vujicic et al.
The British journal of nutrition, 113(5), 770-782 (2015-02-12)
Type 1 diabetes (T1D), an autoimmune inflammatory disorder, develops as a consequence of pancreatic Ī²-cell destruction and results in hyperglycaemia. Since current T1D therapy mainly involves insulin replacement, the aim of the present study was to evaluate the therapeutic potential
Qianying Sheng et al.
Journal of chromatography. A, 1345, 57-67 (2014-05-06)
A-saccharide-based stationary phase for hydrophilic interaction liquid chromatography (HILIC) is presented. The method uses carbonyl di-imidazole (CDI) as a cross-linker for dextran in aqueous solution. Different from the traditional immobilized saccharide stationary phase, this method was using a simple way
Tu Liang et al.
Journal of chromatography. A, 1388, 110-118 (2015-03-03)
A diterpene glycoside compound, rebaudioside A (commonly abbreviated as RA), was immobilized onto porous silica surface through "thiol-ene" click chemistry strategy. The successful immobilization of the RA on the silica support was confirmed by FT-IR and elemental analysis. Chromatographic characteristics
Federica Ianni et al.
Journal of pharmaceutical and biomedical analysis, 116, 40-46 (2015-01-27)
In two-dimensional HPLC (2D-HPLC) "heart-cut" applications, two columns are connected in series via a switching valve and volume fractions from the "primary" column are re-injected on the "secondary" column. The heart-cut 2D-HPLC system here described was implemented by connecting a
Tamar L Greaves et al.
Physical chemistry chemical physics : PCCP, 17(4), 2357-2365 (2014-12-06)
A high-throughput approach was developed in order to prepare and dry a series of protic ionic liquids (PILs) from 48 BrĆønsted acid-base combinations. Many combinations comprised an alkyl carboxylic acid paired with an alkyl amine. Visual screens were developed to
Nicolaas A Verwey et al.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 20(3), 179-187 (2013-07-09)
Abstract Amyloid Ī²-peptide (AĪ²) is a key molecule in Alzheimer's disease (AD). Reliable immunohistochemical (IHC) methods to detect AĪ² and AĪ²-associated factors (AAF) in brain specimens are needed to determine their role in AD pathophysiology. Formic acid (FA) pre-treatment, which
Pavel KubĆ”Å et al.
Analytica chimica acta, 768, 82-89 (2013-03-12)
A simple method using direct injection of human blood samples and quantitative analysis of formate was developed for rapid diagnosis of methanol poisoning. A sample pretreatment device including a 500Da molecular weight cut-off dialysis membrane was in-line coupled to capillary
Amanda C Martin et al.
PloS one, 9(11), e111572-e111572 (2014-11-05)
Formerly used world-wide as a popular botanical medicine to reduce anxiety, reports of hepatotoxicity linked to consuming kava extracts in the late 1990s have resulted in global restrictions on kava use and have hindered kava-related research. Despite its presence on
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