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Showing 1-30 of 901 results for "a1542" within Papers
Yoshiaki Ohtsu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 997, 56-63 (2015-06-21)
We developed and validated bioanalytical methods for a potent helicase-primase inhibitor ASP2151 that has two conformers. These conformers elute as unseparated broad peaks under ordinary high-performance liquid chromatographic conditions, indicating discernable differences in hydrophobicity. We observed that column temperature and
Jan Soukup et al.
Journal of chromatography. A, 1374, 102-111 (2014-12-30)
Excess adsorption of water from aqueous acetonitrile mobile phases was investigated on 16 stationary phases using the frontal analysis method and coulometric Karl-Fischer titration. The stationary phases include silica gel and silica-bonded phases with different polarities, octadecyl and cholesterol, phenyl
Chang-Er Chen et al.
Environment international, 85, 284-291 (2015-10-10)
The occurrence of antibiotics in the environment has raised much concern in recent years. Understanding their release, fate and behaviour in the environment is vital to assess potential risks. In this study, a novel passive water sampler - diffusion gradients
Jin Woo Park et al.
Archives of pharmacal research, 37(12), 1560-1569 (2013-11-21)
Risedronate is widely used clinically to treat osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and multiple myeloma. However, its oral efficacy is restricted due to its low bioavailability and severe gastrointestinal adverse effects. This study was designed to evaluate the effect
Haoyue Zhang et al.
Molecular genetics and metabolism, 114(2), 123-128 (2014-12-03)
Mucopolysaccharidoses (MPS) are complex storage disorders that result in the accumulation of glycosaminoglycans (GAGs) in urine, blood, brain and other tissues. Symptomatic patients are typically screened for MPS by analysis of GAG in urine. Current screening methods used in clinical
Royston S Quintyn et al.
Analytical chemistry, 87(23), 11879-11886 (2015-10-27)
One attractive feature of ion mobility mass spectrometry (IM-MS) lies in its ability to provide experimental collision cross section (CCS) measurements, which can be used to distinguish different conformations that a protein complex may adopt during its gas-phase unfolding. However
Ranganathan Arunkumar et al.
Journal of pharmaceutical sciences, 104(6), 2085-2093 (2015-04-01)
Lutein bioavailability is limited because of its poor aqueous solubility. In this study, lutein-poly (lactic-co-glycolic acid) (PLGA)-polyethylene glycol (PEG) nanocapsules were prepared to improve the solubility, bioavailability, and anticancer property of lutein. The scanning electron microscopy and dynamic light scattering
Sara Castiglioni et al.
Journal of hazardous materials, 282, 51-60 (2014-07-06)
Perfluorinated substances are listed among emerging contaminants because they are globally distributed, environmentally persistent, bioaccumulative and potentially harmful. In a three-year monitoring campaign (2010-2013) we investigated the occurrence, sources and fate of nine perfluoroalkylcarboxylic acids and three perfluoroalkylsulfonic acids, in
J Scott Boone et al.
Journal of chromatography. A, 1345, 68-77 (2014-05-06)
A trace analytical method was developed for the determination of seventeen specific perfluorinated chemicals (PFCs) in environmental and drinking waters. The objectives were to optimize an isotope-dilution method to increase the precision and accuracy of the analysis of the PFCs
Kuniko Mitamura et al.
Steroids, 85, 18-29 (2014-04-12)
A liquid chromatography (LC)/electrospray ionization (ESI)-mass spectrometry (MS) method for the direct determination of eighteen tetrahydrocorticosteroid sulfates in human urine has been developed. The analytes were 3- and 21-monosulfates and 3,21-disulfates of tetrahydrocortisol (THF), tetrahydrocortisone (THE), tetrahydro-11-deoxycortisol (THS), and their
Da-Peng Dai et al.
Basic & clinical pharmacology & toxicology, 117(1), 39-43 (2014-12-04)
Cytochrome P450 2D6 (CYP2D6) is one of the most widely investigated CYPs related to genetic polymorphisms and is responsible for one-quarter of the currently used clinical drugs. We previously detected 22 novel, non-synonymous, mutated sites in the Chinese population, but
Mathias Devreese et al.
Journal of chromatography. A, 1353, 106-113 (2014-03-25)
A specific and sensitive LC-MS/MS method was developed for quantitative determination of closantel in bovine and ovine colostrum and tank milk. Sample preparation consisted of extracting milk samples with acetonitrile/acetone (80/20, v/v) followed by SPE clean-up with Oasis mixed anion
David Moreno-González et al.
Journal of chromatography. A, 1360, 1-8 (2014-08-16)
In this work molecularly imprinted polymers have been evaluated as sorbent for the construction of an in-line solid phase extraction analyte concentrator in capillary electrophoresis coupled with mass spectrometry for the determination of the eight regulated veterinary quinolones in bovine
Alex E Grill et al.
Chemical research in toxicology, 28(7), 1508-1516 (2015-06-27)
Furan, a possible human carcinogen, is found in heat treated foods and tobacco smoke. Previous studies have shown that humans are capable of converting furan to its reactive metabolite, cis-2-butene-1,4-dial (BDA), and therefore may be susceptible to furan toxicity. Human
I Zabaleta et al.
Journal of chromatography. A, 1387, 13-23 (2015-02-25)
An analytical method for the simultaneous determination in fish liver and muscle tissue and mussel samples of 14 perfluorinated compounds (PFCs), including three perfluoroalkylsulfonates (PFSAs), seven perfluorocarboxylic acids (PFCAs), three perfluorophosphonic acids (PFPAs) and perfluorooctanesulfonamide (PFOSA), and 10 potential precursors
Sophie Lissalde et al.
The Science of the total environment, 488-489, 188-196 (2014-05-17)
This study focuses on how Polar Organic Chemical Integrative Samplers (POCIS) work in real environmental conditions. A selection of 23 polar pesticides and 8 metabolites were investigated by exposure of triplicates of integrative samplers in two rivers in France for
Eshwar Jagerdeo et al.
Journal of analytical toxicology, 39(2), 83-88 (2014-11-30)
The abuse of gamma-hydroxybutyric acid (GHB) and its suspicion in cases of suspected drug-facilitated sexual assault is of keen interest to forensic toxicology laboratories. This paper reports an extraction, separation and detection procedure for GHB in hair utilizing a combination
Monika Gibis et al.
Journal of food science, 80(11), C2430-C2439 (2015-10-08)
The impact of precursors such as creatine, creatinine, and glucose on the formation of mutagenic/carcinogenic heterocyclic amines (HAs) were studied in patties of 9 different animal species equally heat treated with a double-plate contact grill. All grilled patties of the
Sarah L Shammas et al.
Nature communications, 6, 7025-7025 (2015-05-01)
Protein aggregation plays a key role in neurodegenerative disease, giving rise to small oligomers that may become cytotoxic to cells. The fundamental microscopic reactions taking place during aggregation, and their rate constants, have been difficult to determine due to lack
Nils Tore Vethe et al.
Therapeutic drug monitoring, 36(1), 108-118 (2013-09-26)
The development of biomarkers describing the individual responses to the immunosuppressant mycophenolic acid (MPA) has focused on the target enzyme activity [inosine 5'-monophosphate dehydrogenase (IMPDH)]. An extended strategy is to quantify the metabolic consequences of IMPDH inhibition. The aim of
Tingting Zhang et al.
Analytical and bioanalytical chemistry, 407(21), 6543-6555 (2015-06-24)
This article describes the development of a lipidomic platform consisting of a 4000 QTRAP mass spectrometer and a self-installed sample inlet system to indentify and quantify 12 phospholipid and five sphingolipid classes from lipid-rich brain tissues of mouse, duck, and
Nagappanpillai Adarsh et al.
Analytical chemistry, 86(18), 9335-9342 (2014-08-26)
With an objective to develop optical probes for biologically important anions and neutral molecules, we synthesized three novel NIR absorbing aza-BODIPY derivatives, 3a-3c, and have systematically tuned their photophysical properties by changing the peripheral substitution. A profound red-shift was observed
Laura Herrero et al.
Analytica chimica acta, 853, 625-636 (2014-12-04)
Phthalates (PAEs) are ubiquitous toxic chemical compounds. During the last few years, some phthalate metabolites (MPAEs) have been proposed as appropriate biomarkers in human urine samples to determine PAE human intake and exposure. So, it is necessary to have fast
Chamila Nimalaratne et al.
Food chemistry, 188, 467-472 (2015-06-05)
Egg white is considered as a rich source of high quality proteins with various bioactive peptide fractions. Enzymatic hydrolysis of proteins can be used to release bioactive fractions and different enzymes have different abilities in releasing such bioactive fractions depending
Merja H Niemi et al.
Scientific reports, 5, 13841-13841 (2015-09-09)
Lipocalins are one of the most important groups of inhalant animal allergens. The analysis of structural features of these proteins is important to get insights into their allergenicity. We have determined two different dimeric crystal structures for bovine dander lipocalin
Maciej Jarosz et al.
Analytica chimica acta, 851, 72-77 (2014-12-03)
Electrospray ionization mass spectrometry (ESI-MS) techniques have been used to characterize the speciation of a Ru(III) anticancer drug, indazolium trans-[tetrachloridobis(1H-indazole) ruthenate(III)], upon its binding to transferrin and the impact of cellular reducing components on drug-transferrin adducts. Using time-of-flight ESI-MS, the
Angelica Guerrero-Castilla et al.
Environmental toxicology and pharmacology, 38(3), 742-750 (2014-10-13)
Exposure to coal dust has been associated with different chronic diseases and mortality risk. This airborne pollutant is produced during coal mining and transport activities, generating environmental and human toxicity. The aim of this study was to determine the effects
Igor Otavio Minatel et al.
Journal of medicinal food, 17(10), 1134-1141 (2014-08-28)
Bioactive components in rice vary depending on the variety and growing condition. Fat-soluble components such as γ-oryzanol, tocopherols, tocotrienols, carotenoids, and fatty acids were analyzed in brown, sugary brown, red, and black rice varieties using established high-performance liquid chromatography (HPLC)
Lakkireddy Prakash et al.
Journal of chromatographic science, 53(1), 122-126 (2014-05-20)
Nicorandil is a potent drug with a dual mechanism of action which results in its wide application in treating angina patients. Since the literature review showed no single preparative method for isolation and liquid chromatography-mass spectrometry (LC-MS) compatible [high-performance liquid
Qizhi Hu et al.
Biomaterials, 53, 370-378 (2015-04-22)
Treatment with chemotherapy such as docetaxel (DTX) is associated with significant toxicity and tumour recurrence. In this study, we developed DTX-entrapped core-cross-linked polymeric micelles (DTX-CCL-PMs, 66 nm size) by covalently conjugating DTX to CCL-PMs via a hydrolysable ester bond. The covalent
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