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Showing 1-30 of 905 results for "A2706" within Papers
Simon Puttick et al.
Molecular imaging, 14, 385-399 (2015-07-29)
Noninvasive imaging is a critical technology for diagnosis, classification, and subsequent treatment planning for patients with glioblastoma. It has been shown that the EphA2 receptor tyrosine kinase (RTK) is overexpressed in a number of tumors, including glioblastoma. Expression levels of
Christine Li Ling Lau et al.
Fundamental & clinical pharmacology, 29(4), 404-416 (2015-05-27)
Tyrosine kinase inhibitor sunitinib (used in GIST, advanced RCC, and pancreatic neuroendocrine tumors) undergoes CYP3A4 metabolism and is an ABCB1B and ABCG2 efflux transporters substrate. We assessed the pharmacokinetic interaction with ibuprofen (an NSAID used by patients with cancer) in
Justyna A Wojdyla et al.
The Journal of biological chemistry, 290(44), 26675-26687 (2015-09-12)
TolR is a 15-kDa inner membrane protein subunit of the Tol-Pal complex in Gram-negative bacteria, and its function is poorly understood. Tol-Pal is recruited to cell division sites where it is involved in maintaining the integrity of the outer membrane.
Timur Baygildiev et al.
European journal of mass spectrometry (Chichester, England), 21(5), 733-738 (2015-11-19)
A new sensitive rapid-separation liquid chromatography tandem mass spectrometry approach for the determination of thiodiglycolic acid (TDGA) in urine has been developed. The use of the "dilute-and-shoot" method helps to shorten the sample preparation stage and provides a sensitive and
Sharon Lai-Fung Chan et al.
Current Alzheimer research, 12(5), 434-438 (2015-05-06)
We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of Ī²-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO(4) 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of AĪ²(1-40) peptide aggregation in vitro, which was
Rebecca Beveridge et al.
Analytical chemistry, 86(22), 10979-10991 (2014-10-30)
In the past decade, mass spectrometry (MS) coupled with electrospray ionization (ESI) has been extensively applied to the study of intact proteins and their complexes, often without the requirement of labels. Solvent conditions (for example, pH, ionic strength, and concentration)
Yan Gao et al.
Marine pollution bulletin, 96(1-2), 226-234 (2015-06-02)
In this study, 54 sediment samples were collected from the Pearl River Estuary (PRE) in Southern China to study the spatial distribution and patterns of PFASs in this region. PFAS concentrations in the sediment samples ranged from nd (below detection
Marion Girod et al.
The Analyst, 139(21), 5523-5530 (2014-09-10)
Improvement of the fragmentation specificity may streamline data processing of bottom-up proteomic experiments by drastically reducing either the amount of MS/MS data to process in the discovery phase or the detection of interfering signals in targeted quantification. Photodissociation at appropriate
Kui Yang et al.
Analytical and bioanalytical chemistry, 407(17), 5199-5210 (2015-03-31)
Diglycerides play a central role in lipid metabolism and signaling in mammalian cells. Although diacylglycerol molecular species comprise the majority of cellular diglycerides that are commonly measured using a variety of approaches, identification of extremely low abundance vinyl ether diglycerides
Zdenka Veprikova et al.
Journal of agricultural and food chemistry, 63(29), 6633-6643 (2015-07-15)
Mycotoxin contamination of dietary supplements represents a possible risk for human health, especially in the case of products intended for people suffering from certain health conditions. The aim of this study was to assess the extent of this problem based
Romchat Chutoprapat et al.
The Journal of pharmacy and pharmacology, 66(7), 943-953 (2014-04-05)
To investigate the influence of the hydrophilic polymer, polyvinylpyrrolidone (PVP) on the ex-vivo permeability of the poorly water-soluble photosensitizer, chlorin e6 (Ce6) using the chick chorioallantoic membrane (CAM) model. The CAM was removed from the fertilized chicken egg at embryo
Jelena MaksiÄ et al.
Journal of chromatographic science, 53(5), 680-686 (2014-10-11)
In this paper, chromatographic analysis of active substance olopatadine hydrochloride, which is used in eye drops as antihistaminic agent, and its impurity E isomer by hydrophilic interaction liquid chromatography (HILIC) and application of design of experiments (DoE) methodology are presented.
Simone Palini et al.
Reproductive biomedicine online, 29(1), 65-71 (2014-05-13)
Ovarian stimulation is used with IVF/intracytoplasmic sperm injection (ICSI) cycles to obtain multiple oocytes and improve pregnancy rates; however, it also induces perturbation in the oxidant-antioxidant balance leading to oxidation stress. The present study monitored the plasma antioxidant status in
Frederik Lermyte et al.
Journal of the American Society for Mass Spectrometry, 26(7), 1068-1076 (2015-04-12)
Non-dissociative charge reduction, typically considered to be an unwanted side reaction in electron transfer dissociation (ETD) experiments, can be enhanced significantly in order to reduce the charge state of intact protein complexes to as low as 1+ on a commercially
Xiaomei Yang et al.
The Science of the total environment, 512-513, 406-414 (2015-02-04)
Repeated applications of glyphosate may contaminate the soil and water and threaten their quality both within the environmental system and beyond it through water erosion related processes and leaching. In this study, we focused on the transport of glyphosate and
Renu Singh et al.
Scientific reports, 5, 13766-13766 (2015-09-09)
A periodic jet of carbon dioxide (CO2) aerosols is a very quick and effective mechanical technique to remove biofilms from various substrate surfaces. However, the impact of the aerosols on the viability of bacteria during treatment has never been evaluated.
Christopher A Quinto et al.
Nanoscale, 7(29), 12728-12736 (2015-07-15)
Superparamagnetic iron oxide (SPIO) nanoparticles have the potential for use as a multimodal cancer therapy agent due to their ability to carry anticancer drugs and generate localized heat when exposed to an alternating magnetic field, resulting in combined chemotherapy and
Rushd Khalaf et al.
Journal of chromatography. A, 1397, 11-18 (2015-05-03)
The purification of therapeutic peptides is most often performed using one or more reversed phase chromatography steps. This ensures high purities while keeping the costs of purification under control. In this paper, a doped reversed phase chromatographic material is tested
Anita Aranyi et al.
Journal of chromatography. A, 1387, 123-133 (2015-02-18)
The direct separation of the enantiomers of 1-(Ī±-aminoarylmethyl)-2-naphthol, 1-(Ī±-aminoalkyl)-2-naphthol, 2-(Ī±-aminoarylmethyl)-1-naphthol analogues and 2-(1-amino-2-methylpropyl)-1-naphthol) was investigated in supercritical fluid chromatography. Five commercially available chiral stationary phases based on immobilized polysaccharide chiral selectors (Chiralpak IA, IB, IC, ID and IE) were evaluated.
Sabine Navis et al.
Aquatic toxicology (Amsterdam, Netherlands), 159, 176-183 (2014-12-30)
Although Daphnia magna is a key species in many lentic freshwater ecosystems and is commonly used as model organism in ecology and ecotoxicology, very little is known about the effects of chemicals on their dormant life stages. Dormant eggs (ephippia)
Joanna Hajduk et al.
Clinica chimica acta; international journal of clinical chemistry, 448, 174-181 (2015-07-15)
An alternative bioinformatics approach based on fuzzy theory statistics and linear discriminant analysis is proposed for the interpretation of MALDI MS spectra in peptide profiling. When applied, the methodology enables the establishment of a reproducible plasma preparation protocol appropriate for
Weidong Cui et al.
Protein science : a publication of the Protein Society, 24(8), 1325-1332 (2015-06-03)
Native spray has the potential to probe biophysical properties of protein assemblies. Here we report an investigation using both ECD top-down sequencing with an FTICR mass spectrometer and ion mobility (IM) measurements on a Q-TOF to investigate the collisionally induced
Fagen Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 976-977, 33-48 (2014-12-23)
2-Hydroxyethylated and oxidative DNA nucleosides (DNA adduct biomarkers), such as O6-(2-hydroxyethyl)-2'-deoxyguanosine (O6HEdG), N6-(2-hydroxyethyl)-2'-deoxyadenosine (N6HEdA), 1-(2-hydroxyethyl)-2'-deoxyadenosine (N1HEdA), and 8-hydroxy-2'-deoxyguanosine (8-OHdG), N2,3-etheno-2'-deoxyguanosine (N2,3-ethenodG), Ī±-methyl-Ī³-hydroxy-1,N2-propano-2'-deoxyguanosine (CrotondG), are important proposed biomarkers for exploring the genotoxicity mechanism of ethylene oxide (EO) in vivo. A liquid
Yaping Zhang et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 19(8), 667-673 (2014-10-31)
Changes in the levels of free fatty acids (FFAs) are closely associated with physiological status. Serum levels of C16:1, C18:3, C18:2, C18:1, C20:4, and C22:6 in 164 gastric cancer (GC) patients and 111 benign gastric disease (BGD) patients were significantly
Sara Granafei et al.
Analytical and bioanalytical chemistry, 407(21), 6391-6404 (2015-05-04)
The numerous and varied biological roles of phosphatidylcholines (PC) and lysophosphatidylcholines (LPC) have fueled a great demand for technologies that enable rapid, in-depth structural examination of these lipids in foodstuffs. Here, we describe the capabilities of a newly configured combination
Kumiko Samejima et al.
The Journal of biological chemistry, 290(35), 21460-21472 (2015-07-16)
The chromosome passenger complex (CPC) is a master regulator of mitosis. Inner centromere protein (INCENP) acts as a scaffold regulating CPC localization and activity. During early mitosis, the N-terminal region of INCENP forms a three-helix bundle with Survivin and Borealin
H Harada et al.
Die Pharmazie, 70(10), 678-683 (2015-11-26)
Although chemical trapping has been widely used to evaluate cytochrome P450-mediated drug bioactivation, thus far, only a few in vitro-trapping studies have been performed on UDP-glucuronosyltransferase (UGT)-mediated drug bioactivation. In this study, we used cysteine (Cys) as trapping agent to
Nazish Ahmed et al.
Tissue engineering. Part A, 20(15-16), 2224-2233 (2014-03-13)
One of the factors preventing clinical application of regenerative medicine to degenerative cartilage diseases is a suitable source of cells. Chondrocytes, the only cell type of cartilage, grown in vitro under culture conditions to expand cell numbers lose their phenotype
Kyle R Pomraning et al.
PloS one, 10(4), e0123188-e0123188 (2015-04-24)
Yarrowia lipolytica is an oleaginous ascomycete yeast that accumulates large amounts of lipids and has potential as a biofuel producing organism. Despite a growing scientific literature focused on lipid production by Y. lipolytica, there remain significant knowledge gaps regarding the
Yufei Chen et al.
Drug design, development and therapy, 8, 1801-1815 (2014-10-23)
Hydroxychloroquine (HCQ) has been shown to demonstrate anti-inflammatory properties and direct anti-HIV activity. In this study, we describe for the first time the fabrication and in vitro evaluation of two types of intravaginal ring (IVR) devices (a surfaced-modified matrix IVR
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