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Showing 1-30 of 314 results for "MAB386" within Papers
Quentin Delarue et al.
Journal of neuroscience research, 99(7), 1835-1849 (2021-05-08)
Spinal cord injury (SCI) is a debilitating condition, which leads to a permanent loss of functions below the injury site. The events which take place after SCI are characterized by cellular death, release of inhibitory factors, and inflammation. Many therapies
Christina Katanov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(32), 6103-6111 (2020-07-01)
Oligodendrocyte myelination depends on actin cytoskeleton rearrangement. Neural Wiskott-Aldrich syndrome protein(N-Wasp) is an actin nucleation factor that promotes polymerization of branched actin filaments. N-Wasp activity is essential for myelin membrane wrapping by Schwann cells, but its role in oligodendrocytes and
Zijian Zhou et al.
Biological & pharmaceutical bulletin, 46(1), 102-110 (2023-01-04)
Peripheral neuropathy is one of the major adverse effects that limit the clinical application of bortezomib (BTZ). However, the underlying mechanisms of BTZ-induced peripheral neuropathy (BIPN) remain elusive. To examine cell types potentially involved in the development of BIPN, we
Gabriella Fernandes-Pires et al.
Molecular therapy. Methods & clinical development, 32(2), 101251-101251 (2024-05-15)
Creatine deficiency syndromes (CDS), caused by mutations in GATM (AGAT), GAMT, and SLC6A8, mainly affect the central nervous system (CNS). CDS show brain creatine (Cr) deficiency, intellectual disability with severe speech delay, behavioral troubles, epilepsy, and motor dysfunction. AGAT/GAMT-deficient patients
Stephanie L Yahn et al.
Neurobiology of disease, 134, 104674-104674 (2019-11-16)
Remyelination failure is a crucial component of disease progression in the autoimmune demyelinating disease Multiple Sclerosis (MS). The regenerative capacity of oligodendrocyte progenitor cells (OPCs) to replace myelinating oligodendrocytes is likely influenced by many aspects of the lesion environment including
Guoqiang Wan et al.
Nature communications, 8, 14487-14487 (2017-02-18)
Hidden hearing loss (HHL) is a recently described auditory neuropathy believed to contribute to speech discrimination and intelligibility deficits in people with normal audiological tests. Animals and humans with HHL have normal auditory thresholds but defective cochlear neurotransmission, that is
Xiaona Feng et al.
Communications biology, 3(1), 716-716 (2020-11-29)
Transient receptor potential vanilloid 4 (TRPV4) is a non-selective calcium-permeable cation channel that is widely expressed and activated in various neurons and glial cells in the nervous system. Schwann cells (SCs) are primary glia cells that wrap around axons to
Reza Nasrnezhad et al.
Molecular neurobiology, 58(11), 5473-5493 (2021-08-03)
Inflammation, demyelination, glial activation, and oxidative damage are the most pathological hallmarks of multiple sclerosis (MS). Piperine, a main bioactive alkaloid of black pepper, possesses antioxidant, anti-inflammatory, and neuroprotective properties whose therapeutic potential has been less studied in the experimental
Masahiro Otsu et al.
Frontiers in cell and developmental biology, 9, 688283-688283 (2021-09-11)
Embryonic stem cells (ESC) have the potential to generate homogeneous immature cells like stem/progenitor cells, which appear to be difficult to isolate and expand from primary tissue samples. In this study, we developed a simple method to generate homogeneous immature
Chang Hwa Jung et al.
Molecular biology of the cell, 20(7), 1992-2003 (2009-02-20)
Autophagy, the starvation-induced degradation of bulky cytosolic components, is up-regulated in mammalian cells when nutrient supplies are limited. Although mammalian target of rapamycin (mTOR) is known as the key regulator of autophagy induction, the mechanism by which mTOR regulates autophagy
Padma Kadiyala et al.
ACS nano, 13(2), 1365-1384 (2019-02-06)
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor, for which there is no cure. Treatment effectiveness for GBM has been limited due to tumor heterogeneity, an immunosuppressive tumor microenvironment (TME), and the presence of the blood-brain barrier, which hampers
Ji-Young Kim et al.
Royal Society open science, 6(6), 190266-190266 (2019-07-18)
Treatment of multiple sclerosis is effective when anti-inflammatory, neuroprotective and regenerative strategies are combined. Dendropanax morbiferus (DM) has anti-inflammatory, anti-oxidative properties, which may be beneficial for multiple sclerosis. However, there have been no reports on the effects of DM on
Yun Jeong Mo et al.
Methods and protocols, 5(4) (2022-07-28)
A co-culture of neurons and Schwann cells has frequently been used to investigate myelin sheath formation. However, this approach is restricted to myelin-related diseases of the peripheral nervous system. This study introduces and compares an ex vivo model of adult-mouse-derived
Haritha L Desu et al.
Cells, 10(7) (2021-08-08)
Multiple sclerosis (MS) is a neuroimmune disorder characterized by inflammation, CNS demyelination, and progressive neurodegeneration. Chronic MS patients exhibit impaired remyelination capacity, partly due to the changes that oligodendrocyte precursor cells (OPCs) undergo in response to the MS lesion environment.
Giacomo Valle et al.
Biomaterials, 291, 121874-121874 (2022-11-06)
Bioelectronic medicine is a promising venue for treatment of disabilities using implantable neural interfaces. Peripheral neurostimulation of residual nerves recently enabled multiple functional benefits in amputees. Despite the preliminary promising impact on patients' life, the over-time stability of implants and
Compromised Myelin and Axonal Molecular Organization Following Adult-Onset Sulfatide Depletion.
Dustin, et al.
Biomedicines, 11 (2023)
Yongqiang Wu et al.
Molecular brain, 15(1), 33-33 (2022-04-13)
Abnormal white matter is a common neurobiological change in bipolar disorder, and dysregulation of myelination in oligodendrocytes (OLs) is the cause. Transmembrane protein 108 (Tmem108), as a susceptible gene of bipolar disorder, is expressed higher in OL lineage cells than
Liana R Stein et al.
The EMBO journal, 33(12), 1321-1340 (2014-05-09)
Neural stem/progenitor cell (NSPC) proliferation and self-renewal, as well as insult-induced differentiation, decrease markedly with age. The molecular mechanisms responsible for these declines remain unclear. Here, we show that levels of NAD(+) and nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in
Joshua E Burda et al.
Nature, 606(7914), 557-564 (2022-05-26)
Astrocytes respond toĀ injury and disease in the central nervous system with reactive changes that influence the outcome of the disorder1-4. These changes include differentially expressed genes (DEGs) whose contextual diversity and regulation are poorly understood. Here we combined biological and
Jane Ryu et al.
Scientific reports, 11(1), 8620-8620 (2021-04-23)
Traumatic brain injury (TBI) is a common phenomenon, accounting for significant cost and adverse health effects. While there is information about focal pathologies following TBI, knowledge of more diffuse processes is lacking, particularly regarding how analgesics affect this pathology. As
Ying-Chang Lu et al.
JCI insight, 7(20) (2022-10-25)
Recessive PJVK mutations that cause a deficiency of pejvakin, a protein expressed in both sensory hair cells and first-order neurons of the inner ear, are an important cause of hereditary hearing impairment. Patients with PJVK mutations garner limited benefits from
Cynthia B Ripoll et al.
Stem cells (Dayton, Ohio), 29(1), 67-77 (2011-02-01)
The twitcher mouse is an animal model of Krabbe's disease (KD), which is a neurodegenerative lysosomal storage disorder resulting from the absence of functional lysosomal enzyme galactocerebrosidase (GALC). This disease affects the central and peripheral nervous systems and in its
Anuriti Aojula et al.
Fluids and barriers of the CNS, 13(1), 9-9 (2016-06-02)
In an effort to develop novel treatments for communicating hydrocephalus, we have shown previously that the transforming growth factor-Ī² antagonist, decorin, inhibits subarachnoid fibrosis mediated ventriculomegaly; however decorin's ability to prevent cerebral cytopathology in communicating hydrocephalus has not been fully
Stanislaw Mitew et al.
Nature communications, 9(1), 306-306 (2018-01-24)
Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which neuronal activity is capable of regulating myelination at the individual axon level is unclear. Here we demonstrate that stimulation of
Tal Iram et al.
Nature, 605(7910), 509-515 (2022-05-12)
Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain ageing1-3. Cerebrospinal fluid (CSF) makes up the immediate environment of brain cells, providing them with nourishing compounds4,5. We discovered
Monica R Langley et al.
Biochimica et biophysica acta. Molecular basis of disease, 1866(3), 165630-165630 (2019-12-10)
Metabolic syndrome is a key risk factor and co-morbidity in multiple sclerosis (MS) and other neurological conditions, such that a better understanding of how a high fat diet contributes to oligodendrocyte loss and the capacity for myelin regeneration has the
Konstantin Feinberg et al.
Neuron, 65(4), 490-502 (2010-03-02)
Saltatory conduction requires high-density accumulation of Na(+) channels at the nodes of Ranvier. Nodal Na(+) channel clustering in the peripheral nervous system is regulated by myelinating Schwann cells through unknown mechanisms. During development, Na(+) channels are first clustered at heminodes
Meredith D Hartley et al.
JCI insight, 4(8) (2019-04-19)
Oligodendrocyte processes wrap axons to form neuroprotective myelin sheaths, and damage to myelin in disorders, such as multiple sclerosis (MS), leads to neurodegeneration and disability. There are currently no approved treatments for MS that stimulate myelin repair. During development, thyroid
Vicki J Swier et al.
PloS one, 15(2), e0228222-e0228222 (2020-02-20)
Genetically modified swine disease models are becoming increasingly important for studying molecular, physiological and pathological characteristics of human disorders. Given the limited history of these model systems, there remains a great need for proven molecular reagents in swine tissue. Here
James Keaney et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 14(3), 448-461 (2019-02-14)
Bruton's tyrosine kinase (BTK), a critical component of B cell receptor signaling, has recently been implicated in regulation of the peripheral innate immune response. However, the role of BTK in microglia, the resident innate immune cells of the central nervous
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