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Don Coltart

Professor Don Coltart

Synthetic organic chemistry is the unifying feature of all research in the Coltart Group. We have a particular interest in the development of new synthetic methods and the use of those methods to enable the total synthesis of structurally complex, biologically active natural products. Our methodology research focuses mainly on asymmetric carbon–carbon bond formation – with an emphasis on the
α-alkylation of carbonyl compounds – as well as the synthesis of saturated and partially saturated heterocyclic compounds.

Coltart Group Website

Recent papers from the Coltart Group

1.
Huynh U, McDonald SL, Lim D, Uddin MN, Wengryniuk SE, Dey S, Coltart DM. 2018. Formation, Alkylation, and Hydrolysis of Chiral Nonracemic N-Amino Cyclic Carbamate Hydrazones: An Approach to the Enantioselective α-Alkylation of Ketones. J. Org. Chem.. 83(21):12951-12964. http://dx.doi.org/10.1021/acs.joc.8b00655
2.
Wengryniuk SE, Lim D, Coltart DM. 2011. Regioselective Asymmetric α,α-Bisalkylation of Ketones via Complex-Induced Syn-Deprotonation of Chiral N-Amino Cyclic Carbamate Hydrazones. J. Am. Chem. Soc.. 133(22):8714-8720. http://dx.doi.org/10.1021/ja202267k
3.
Lim D, Coltart D. 2008. Simple and Efficient Asymmetric α-Alkylation and α, α-Bisalkylation of Acyclic Ketones by Using Chiral N-Amino Cyclic Carbamate Hydrazones. Angew. Chem. Int. Ed.. 47(28):5207-5210. http://dx.doi.org/10.1002/anie.200800848

DISCIPLINES

  • Organic Synthetic Chemistry
  • Catalysis

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