ACO1
aconitase 1, soluble
Synonyms:
ACONS, IREB1, IREBP, IREBP1, IRP1
Species:
Human ACO1 (48), Mouse Aco1 (11428), Rat Aco1 (50655), domestic cat ACO1 (101095526), Thale Cress ACO1 (816478), dog ACO1 (481576), sheep ACO1 (101112791), cow ACO1 (512995), Zebrafish aco1 (568448), Thale Cress ACO1 (829737) ...More
UniProtKB ID:
Gene ID:
- Human(48) Summary: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
- Mouse(11428) aconitase 1
- Rat(50655) aconitase 1, soluble
- domestic cat(101095526) aconitase 1, soluble
- Thale Cress(816478) 1-aminocyclopropane-1-carboxylate oxidase 1
- dog(481576) aconitase 1, soluble
- sheep(101112791) aconitase 1, soluble
- cow(512995) aconitase 1, soluble
- Zebrafish(568448) aconitase 1, soluble
- Thale Cress(829737) aconitate hydratase 1
- Horse(100067866) aconitase 1, soluble
- chicken(373916) aconitase 1, soluble
- naked mole-rat(101716545) aconitase 1, soluble
- domestic guinea pig(100720793) aconitase 1, soluble
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