Skip to Content
Merck

APP

amyloid beta (A4) precursor protein

Synonyms:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
Species:
Human APP (351), Mouse App (11820), Rat App (54226), fruit fly app (39399), chicken APP (374198), dog APP (403407), domestic cat APP (101085564), cow APP (280722), sheep APP (101111593), domestic guinea pig App (100715302)
UniProtKB ID:
P05067, B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438
Gene ID:
  • Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11820) amyloid beta (A4) precursor protein
  • Rat(54226) amyloid beta (A4) precursor protein
  • fruit fly(39399) approximated
  • chicken(374198) amyloid beta (A4) precursor protein
  • dog(403407) amyloid beta (A4) precursor protein
  • domestic cat(101085564) amyloid beta (A4) precursor protein
  • cow(280722) amyloid beta (A4) precursor protein
  • sheep(101111593) amyloid beta (A4) precursor protein
  • domestic guinea pig(100715302) amyloid beta (A4) precursor protein
  • naked mole-rat(101724743) amyloid beta (A4) precursor protein

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
EZHS42
High Sensitivity Human Amyloid β42 ELISA, ,
Species
human
EZHS40
High Sensitivity Human Amyloid β40 ELISA, ,
Species
human
EZBRAIN42
Human Amyloid β42 Brain ELISA, ,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
B9934
BTA-1, ≥98% (HPLC), solid,
Species
human
C1386
Curcumin, from Curcuma longa (Turmeric), powder,
Species
human
C7727
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin),
Species
human
F8514
Flurbiprofen, cyclooxygenase inhibitor,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
A3981
Anti-β-Amyloid antibody, Mouse monoclonal, clone BAM-10, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
MABN687
Anti-β-amyloid fibril-specific, clone B10, AP Antibody, clone B10, from camel, alkaline phosphatase conjugate,
Species Reactivity
human
Application
ELISA
dot blot
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
MABN639
Anti-Amyloid βA4, clone 1E8 (Amino Terminus) Antibody, clone 1E8, 1 mg/mL, from mouse,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
AB1510
Anti-Amyloid β Antibody, aa1-14 h β-amyloid, serum, Chemicon®,
Species Reactivity
human
Application
immunohistochemistry
western blot
MAB348A4
Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj., clone 22C11, from mouse, ALEXA FLUOR™ 488,
Species Reactivity
canine, human, monkey, mouse, pig, porcine, rat
Application
immunocytochemistry
immunohistochemistry

Proteins

Product Number
Description
Species
A2201
Amyloid β-Protein Fragment 35-25, ≥95% (HPLC),
Species
human
A5080
Amyloid β-Protein Fragment 22-35, ≥95% (HPLC),
Species
human
A6933
Acetyl-Amyloid β-Protein Fragment 15-20 Amide, ≥97% (HPLC), powder,
Species
human
S4316
Amyloid Precursor Protein β, Secreted human, recombinant, expressed in E. coli (N-terminal histidine tagged), solution,
Species
human
SCP0029
[Gly22]-Amyloid β 1-40 Arctic human, ≥95% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
EHU085701
MISSION® esiRNA, targeting human APP,
Species
human
EMU012021
MISSION® esiRNA, targeting mouse App,
Species
mouse